Association of A-FABP gene polymorphism in intron 1 with meat quality traits in Junmu No. 1 white swine

文献类型： 外文期刊

第一作者： Gao, Yan

作者： Gao, Yan;Li, Fujuan;Wang, Shuai;Dai, Lisheng;Jiang, Hao;Liu, Dianfeng;Zhao, Zhihui;Zhang, Jiabao;Zhang, Yonghong;Sun, Boxing;Zhang, Shumin;Xiao, Shuqi

作者机构：

关键词： Junmu No. 1 white swine;A-FABP;Intron 1;Polymorphism;Protein expression;Meat quality

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2011 年 487 卷 2 期

页码：

收录情况： SCI

摘要： This study was designed to investigate the single nucleotide polymorphism (SNP) in intron 1 of the gene A-FABP in 127 Junmu No. 1 white swine using PCR-SSCP. The association between the polymorphism and meat quality traits was also studied. The cloning and sequencing results indicated that the polymorphism of intron 1 was due to a point mutation in position 3481 bp of A-FABP, giving 3 genotypes (CC, CD and DD). Association analysis indicated that the polymorphism had a significant effect on marbling (P<0.05). Genotype DD had higher marbling than CD and CC, but the difference between CD and CC was no significant. Polymorphism had a highly significant effect on intramuscular fat (IMF) content (P<0.01). DD was higher than CD, which was higher than CC. No significant conclusions can be drawn regarding other traits. Immunoblot analysis of A-FABP levels was carried out on 3 different genotype individuals. Expression was markedly reduced in DD compared with genotype CC. Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits. (C) 2011 Elsevier B.V. All rights reserved.

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