Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells
文献类型: 外文期刊
第一作者: Su, Chun-xia
作者: Su, Chun-xia;Feng-Wang;Zheng, Jie;Ling-Huang;Wang, Ning-ping;Duan, Xiang-guo;Duan, Xiang-guo;Duan, Xiang-guo;Liang, Li-jun;Fu, Xue-Yan;Yan, Ya-mei
作者机构:
关键词: Lycium barbarum polysaccharides;Follicular helper T cells;Adjuvant
期刊名称:VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY ( 影响因子:2.046; 五年影响因子:2.217 )
ISSN: 0165-2427
年卷期: 2014 年 158 卷 1-2 期
页码:
收录情况: SCI
摘要: Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immunemodulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In our current study, we found that LBP were able to activate CXCR5+PD-1+ Tfh cells and induce IL-21 secretion. At the same time LBP also promoted the formation of germinal centers (GC) and production of GL-7+B220+GC B cells. LBP as an adjuvant could increase generation of rAd5VP1-induced Tfh cells. Our results indicate that LBP might enhance T cell-dependent Ab responses by acting as an adjuvant for the generation of Tfh cells. Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects. (C) 2013 Elsevier B.V. All rights reserved.
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