Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide

文献类型： 外文期刊

第一作者： Qu, Jian-Qiang

作者： Qu, Jian-Qiang;Yang, Qiu-Hua;Qu, Ling;Wang, Liu-Fang

作者机构：

关键词： transition metal;complexes;podophyllic acid hydrazide;anti-tumor activities

期刊名称：CHEMICAL PAPERS （ 影响因子：2.097； 五年影响因子：1.831 ）

ISSN： 0366-6352

年卷期： 2009 年 63 卷 4 期

页码：

收录情况： SCI

摘要： Four transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, and (1)H NMR. The complexes have the general formula ML(2) center dot nH(2)O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL(2) center dot (2)H(2)O, and NiL(2) were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin.

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