Nephroprotective effects of diacylglycerol on diabetic nephropathy in type 2 diabetic rats

文献类型： 外文期刊

第一作者： Li, Jianpeng

作者： Li, Jianpeng;Yan, Yongheng;Li, Xia;Liu, Zhenhua;Xu, Tongcheng;Du, Fangling;Li, Duo;Lin, Xinying;Liu, Zhenhua

作者机构：

关键词： diacylglycerol;diabetic nephropathy;advanced glycation end products;transforming growth factor-beta 1

期刊名称：EXPERIMENTAL AND THERAPEUTIC MEDICINE （ 影响因子：2.447； 五年影响因子：2.263 ）

ISSN： 1792-0981

年卷期： 2018 年 15 卷 2 期

页码：

收录情况： SCI

摘要： Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weight streptozocin, and the disease developed over the following 8 weeks. Sprague-Dawley rats were then randomly divided into the control, TAG, low-dose DAG (Low-DAG) and high-dose DAG (High-DAG) groups. Blood glucose (BG), lipid levels and renal function parameters were then measured. The results revealed that the body weight in the High-DAG group was significantly reduced compared with the TAG group, while there was no significant difference in the food intake between TAG and DAG groups. BG, advanced glycation end products (AGEs), TAG, low-density lipoprotein cholesterol, urine protein and urine albumin levels were significantly reduced, while high-density lipoprotein cholesterol levels were significantly increased in the two DAG groups. In addition, hematoxylin-eosin stained glomeruli presented decreased glomerular enlargement and mesangial expansion in the DAG groups. Immunohistochemical detection revealed that the levels of transforming growth factor-beta 1 and connective tissue growth factor in renal tissues of the DAG groups were also significantly reduced compared with the TAG group. These findings indicate that DAG oils can significantly reduce BG levels and the deposition of AGEs in renal tissue, as well as regulate the levels of transforming growth factor-beta 1 and connective tissue growth factor, thus delaying the progression of nephropathy.

分类号：

  • 相关文献

[1]Effect of Diacylglycerol Supplementation on Fasting Serum Triacylglycerol Concentration: a Meta-Analysis. Wang, Wenliang,Xu, Tongcheng,Zhu, Qingjun,Cheng, Anwei,Du, Fangling,Xu, Tongcheng,Li, Duo,Li, Xia. 2010

[2]Effect of Diacylglycerol on Postprandial Serum Triacylglycerol Concentration: A Meta-analysis. Xu, Tongcheng,Zhang, Zhiguo,Li, Duo,Li, Xia,Xu, Tongcheng,Ma, Xiaohang,Zhang, Tiansong. 2009

[3]Effect of diacylglycerol on body weight: a meta-analysis. Xu, Tongcheng,Zhang, Zhiguo,Li, Duo,Xu, Tongcheng,Li, Xia,Ma, Xiaohang. 2008

[4]Effect of Acylglycerol Composition and Fatty Acyl Chain Length on Lipid Digestion in pH-Stat Digestion Model and Simulated In Vitro Digestion Model. Qi, Jin F.,Jia, Cai H.,Shin, Jung A.,Woo, Jeong M.,Wang, Xiang Y.,Park, Jong T.,Hong, Soon T.,Lee, K-T.,Qi, Jin F..

[5]Ability of resveratrol to inhibit advanced glycation end product formation and carbohydrate-hydrolyzing enzyme activity, and to conjugate methylglyoxal. Shen, Yixiao,Sheng, Zhanwu,Shen, Yixiao,Xu, Zhimin. 2017

[6]Cynarin-Rich Sunflower (Helianthus annuus) Sprouts Possess Both Antiglycative and Antioxidant Activities. Sun, Zheng,Chen, Feng,Sun, Zheng,Chen, Jingnan,Jiang, Yue,Ma, Jinyu,Wang, Mingfu,Ren, Guixing.

[7]Physicochemical Changes and Glycation Reaction in Intermediate-Moisture Protein-Sugar Foods with and without Addition of Resveratrol during Storage. Sheng, Zhanwu,Gu, Mantun,Hao, Wangjun,Shen, Yixiao,Zheng, Lili,Ai, Binling,Zheng, Xiaoyan,Sheng, Zhanwu,Zhang, Weimin,Xu, Zhimin.

[8]Major Phenolic Compounds, Antioxidant Capacity and Antidiabetic Potential of Rice Bean (Vigna umbellata L.) in China. Yao, Yang,Cheng, Xu-Zhen,Wang, Li-Xia,Wang, Su-Hua,Ren, Guixing. 2012

[9]Influence of altitudinal variation on the antioxidant and antidiabetic potential of azuki bean (Vigna angularis). Yao, Yang,Cheng, Xuzhen,Wang, Suhua,Wang, Lixia,Ren, Guixing. 2012

[10]Three different active aldehydes induce the production of advanced lipoxidation end products upon incubation with bovine serum albumin. Li, Wenjuan,Gao, Haiyan,Li, Wenjuan,Gao, Haiyan,Mu, Honglei,Chen, Hangjun,Fang, Xiangjun,Zhou, Yongjun,Tao, Fei.

作者其他论文 更多>>

微信小程序