Antioxidant activity of Phellinus igniarius fermentation mycelia contributions of different solvent extractions and their inhibitory effect on α-amylase

文献类型： 外文期刊

第一作者： Dong, Yating

作者： Dong, Yating;Wang, Tao;Gan, Bingcheng;Zhao, Jin;Duan, Xinlian;Cao, Luping;Feng, Rencai;Miao, Renyun;Yan, Junjie;Wu, Zhi;Dong, Yating;Wang, Tao;Gan, Bingcheng;Zhao, Jin;Duan, Xinlian;Cao, Luping;Feng, Rencai;Miao, Renyun;Yan, Junjie;Wu, Zhi;Wasser, Solomon P.;Wasser, Solomon P.;Zhang, Zhiyuan

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关键词： Phellinus igniarius QB72; Fermentation mycelia; Polysaccharides; alpha-amylase inhibitory

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

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年卷期： 2024 年 10 卷 1 期

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收录情况： SCI

摘要： Phellinus spp. have historically been used as traditional medicines to treat various diseases owing to their antioxidant, antitumor, and antidiabetic activities. Polysaccharides exhibit antidiabetic activity. In the present study, the polysaccharide contents of four Phellinus strains were compared. Phellinus igniarius QB72 possessed higher polysaccharide production, stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, and alpha-amylase inhibitory activity. The three polysaccharides were sequentially extracted and partially purified from the fermentation mycelia using hot water, 1 % (NH4)(2)C2O4, and 1.25 M NaOH. Hot water extract polysaccharides exhibited higher DPPH radical scavenging and strong inhibitory activity against alpha-amylase with an IC50 value of 6.84 +/- 0.37 mg/mL. The carbohydrate content of A1 (approximately 17457 Da) was approximately 88.28 %. The alpha-amylase inhibitory activity IC50 was decreased (3.178 +/- 0.187 mg/mL) after DEAE water elution. P. igniarius QB72 hot-water extracts of partially purified polysaccharides have great potential as alpha-amylase inhibitors in food and medication-assisted additives.

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