Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro
文献类型: 外文期刊
第一作者: Wang, Dan
作者: Wang, Dan;Mu, Yan;Dong, Hongjing;Yan, Huijiao;Hao, Cui;Wang, Xiao;Wang, Dan;Zhang, Lisi
作者机构:
关键词: Diaphragma juglandis fructus;chemical constituents;high-speed counter-current chromatography;preparative separation;anti-inflammatory activity
期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )
ISSN: 1420-3049
年卷期: 2018 年 23 卷 1 期
页码:
收录情况: SCI
摘要: Diaphragma juglandis fructus contains various bioactive constituents. Fourteen compounds were isolated from Diaphragma juglandis fructus by preparative high performance liquid chromatography (pre-HPLC) and high-speed counter-current chromatography (HSCCC). Their structures were identified by nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESI-MS). Compounds (+)-dehydrovomifoliol (12), (6R,9R)-9-hydroxymegastigman-4-en-3-one (13) and (6R,9S)-9-hydroxymegastigman-4-en-3-one (14) are found from Juglans regia L. for the first time. Compounds dihydrophaseic acid (2), blumenol B (3) and (4S)-4-hydroxy-1-tetralone (11) are isolated from Diaphragma juglandis fructus for the first time. The anti-inflammatory effects of isolated compounds were evaluated by an in vitro model of lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds gallic acid (1), ethyl gallate (9) and (+)-dehydrovomifoliol (12) exhibited inhibitory activity on the nitric oxide production of RAW 264.7 at a concentration of 25 M. The result indicated that the combination HSCCC with pre-HPLC is an effective way for compound separation and purification. And Diaphragma juglandis fructus constituents have the potential for the treatment of inflammatory-related diseases.
分类号:
- 相关文献
作者其他论文 更多>>
-
Analysis of the steady-state concentrations of reactive species and their role in contaminant degradation by the iron-biochar/persulfate advanced oxidation process: Comparison of probe compound and quenching agent methods
作者:Meng, Xukun;Peng, Guilong;Yan, Yuting;Wang, Xiao;Zhu, Jiangwei;Belver, Carolina;Gong, Wenwen;Blaney, Lee;Peng, Guilong
关键词:Reactive species; Persulfate; Steady-state concentration; Iron-biochar; Advanced oxidation processes
-
Unraveling novel antioxidant peptides from Asian swamp eel: Identification, in silico selection, and mechanistic insights through quantum chemical calculation and molecular docking
作者:Wang, Xiao;Fu, Juan;Chen, Bingjie;Liu, Hongru;Wu, Songheng;He, Hui;Wang, Qiankun;Qiao, Yongjin;Zhou, Wenzong;Bhullar, Khushwant S.;Su, Di
关键词:Asian swamp eel; Antioxidant activity; In silico selection; Quantum chemistry calculation; Molecular docking
-
Variation in microbial communities and network ecological clusters driven by soil organic carbon in an inshore saline soil amended with hydrochar in Yellow River Delta, China
作者:Yao, Hui;Cheng, Yadong;Kong, Qingxian;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Yao, Hui;Cheng, Yadong;Wang, Xiao;You, Xiangwei;Li, Yiqiang;Rong, Ziguo;Quan, Yue;Zheng, Hao
关键词:Soil carbon; Hydrochar; Soil microorganism; Ecological cluster; Coastal salt-affected soil; Soil health
-
Purification Effect and Microbial Community Analysis of Aquaculture Wastewater Using High-Efficiency and Stable Biochemical System
作者:Su, Lei;Su, Yuting;Wu, Shanshan;Gao, Hang;Wu, Hangtao;Yang, Minghui;Li, Yaying;Wang, Dan;Lu, Yusheng;Zhang, Kun;Gu, Wenjie;Peng, Huanlong;Zhou, Donglai
关键词:aquaculture wastewater; microbial community; pollutant removal; stable bioreactor
-
Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil
作者:Pan, Xin;Kuang, Shaoping;Wang, Xiao;Ullah, Habib;Rao, Zepeng;Ali, Esmat F.;Abbas, Qumber;Lee, Sang Soo;Shaheen, Sabry M.
关键词:Soil amendment; Heavy metal; Hydrotalcite; Surface modification; Environmental resistance
-
Trace phospholipid and fatty acid differences between dairy and plant-based milk products by 1 H and 31 P NMR spectroscopy combined with multivariate statistical analysis
作者:Wang, Tongtong;Tan, Sijia;Li, Liang;Jiang, Bin;Wang, Dan;Liu, Qingyi;Chen, Gang
关键词:Dairy cream; Butter; Plant-based cream; Margarine; Multivariate statistical analysis
-
Metabolomics combined with biochemical analyses revealed phenolic profiles and antioxidant properties of rapeseeds
作者:Zhang, Yao;Lv, Xin;Wang, Dan;Zheng, Chang;Chen, Hong;Wei, Fang;Zhang, Yao;Yuan, Yongjun;Wei, Fang
关键词:Rapeseed; Phenolic compounds; Untargeted metabolomics; Molecular networking; Antioxidant activities