SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle

文献类型： 外文期刊

第一作者： Liu, Guifen

作者： Liu, Guifen;Zhao, Hongbo;Tan, Xiuwen;Cheng, Haijian;You, Wei;Wan, Fachun;Liu, Yifan;Song, Enliang;Liu, Xiaomu;Liu, Guifen;Zhao, Hongbo;Tan, Xiuwen;Cheng, Haijian;You, Wei;Wan, Fachun;Liu, Yifan;Song, Enliang;Liu, Xiaomu

作者机构：

期刊名称：ARCHIVES ANIMAL BREEDING （ 影响因子：1.528； 五年影响因子：1.723 ）

ISSN： 0003-9438

年卷期： 2017 年 60 卷 1 期

页码：

收录情况： SCI

摘要： SIRT1 is the gene that codes for Sirtuin 1, an NAD (nicotinamide adenine dinucleotide)-dependent class III histone deacetylase. This gene plays a key role in adipose tissue and muscle development in animals. Chinese Luxi cattle (n = 169) were selected to identify SIRT1 SNPs (single nucleotide polymorphisms) and investigate the relationship of these SNPs with carcass traits. Five SNPs (g.=382G > A, g.=274C > G, g.17324T > C, g.17379A > G, and g.17491G > A) were identified by direct sequencing. SNPs g.-382G > A and g.-274C > G were located within the promoter region of this gene. SNP g.-382G > A was significantly associated with dressing percentage, meat percentage, and striploin and ribeye weights, and the g.-274C > G polymorphism had a strong effect on carcass, tenderloin, and high rib weights in Luxi cattle. These findings will provide possible clues for the biological roles of SIRT1 underlying beef cattle carcass traits.

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