Kinetics of PCDD/Fs from feed to cow milk and its implications for food safety

文献类型： 外文期刊

第一作者： Hao, Yanfen

作者： Hao, Yanfen;Wang, Pu;Hao, Yanfen;Wang, Chu;Xian, Hao;Liu, Mei;Li, Zengwei;Ma, Jie;Li, Yingming;Yang, Ruiqiang;Zhang, Qinghua;Jiang, Guibin;Wang, Chu;Xian, Hao;Liu, Mei;Li, Zengwei;Ma, Jie;Zhang, Qinghua;Jiang, Guibin;Cheng, Jie;Su, Xiaoou

作者机构：

关键词： PCDD; Fs; Scale andprofile; Transfer rate; Mass balance measure

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 874 卷

页码：

收录情况： SCI

摘要： Guideline levels of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) in feed and food have been sepa-rately recommended for the official food safety control around the world. However, less is considered about the trans-fer effect of PCDD/Fs from feed to food, and consequently possible human exposure risk. In this study, different controlled feeding experiments (E1 group: 4.92 pg TEQ/g in feed, E2 group: 0.61 pg TEQ/g in feed) were conducted on dairy cow (Chinese Holstein breed) to evaluate kinetics of PCDD/Fs from feed to milk and blood. Even though the PCDD/F level in feed in E2 was satisfied with the EU Regulation (No 277/2012), the TEQ levels in milk and tissues exceeded the European Union maximum level (EU ML) after approximately one-week exposure. The dynamic varia-tion in milk during the initial 20-day exposure was successfully described by a first-order kinetic model. The levels at the plateau period showed a significant linear relationship (p < 0.01, R2 = 0.98) against the intake amounts from feed. Based on modeling, a maximum content was obtained at approximately 0.33 pg TEQ/g in cow feed with 12 % moisture to ensure the milk and meat safety under the current regulatory requirements of EU for cow-origin food. After the cease of exposure, the PCDD/F levels in milk declined below the EU ML within 40 days, while those in meat were still higher than the EU ML over 160 days. In serum, PCDD/Fs detected in E1 showed a similar dynamic variation during the exposure period. Regarding congener profile, higher-chlorinated congeners tended to transfer from feed to feces, whereas lower ones were preferably transferred into milk, which required specific concern about the metabolic effect of PCDD/Fs in large mammals. This study revealed a necessity for re-evaluation of official regula-tion on pollutants in cow feed and cow-origin food in terms of biotransfer and bioaccumulation.

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