Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene

文献类型： 外文期刊

第一作者： Liu, D.

作者： Liu, D.;Xu, Q.;Zang, L.;Liang, S.;Jiang, Y.;Wu, Y.;Wei, S.

作者机构：

关键词： early growth traits;haplotype;myostatin gene;pig;promoter;transcription

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

ISSN： 0268-9146

年卷期： 2011 年 42 卷 1 期

页码：

收录情况： SCI

摘要： P>Myostatin plays a pivotal role in controlling skeletal muscle mass in mammals. Polymorphisms in its promoter region likely impact on transcription and production traits. In this study, haplotypes involving three polymorphic sites in the promoter region of the porcine myostatin gene, namely at sites 435, 447 and 879, were identified and their effect on production traits, gene expression as well as on skeletal muscle traits were analysed. Four haplotypes were revealed and the linkage disequilibrium and evolutionary relationship were assessed. The results revealed that haplotypes A, B and C are predominant in Yorkshire and Landrace, Duroc and two Chinese indigenous pig breeds (Laiwu and Dapulian) respectively. The genotypes are associated with body weight on day 21 (BW21), average daily gain from birth to day 21 (ADG1) and average daily gain from day 21 to day 70 (ADG2) (P < 0.05) in Duroc pigs. The activity of haplotype A (pGL3-A) is significantly higher than other constructs in driving reporter gene transcription (P < 0.01). As compared with CC animals, the myostatin mRNA level in BC animals is relatively lower in both semimembranosus (SM) and semitendinosus (ST) skeletal muscles, and the difference was significant in the SM muscle (P < 0.01). Moreover, the mRNA levels of MyHCI, MyHCIIa, MyHCIIb and MyHCIIx and the muscle fibre diameter and density were also compared between BC and CC animals.

分类号：

  • 相关文献

[1]Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene. Xia, Jihan,Hu, Bingjun,Mu, Yulian,Xin, Leilei,Yang, Shulin,Li, Kui.

[2]The ecdysteroid UDP-glucosyltransferase gene promoter from Autographa californica multicapsid nucleopolyhedrovirus. Shen, XJ,Yi, YZ,Tang, SM,Zhang, ZF,Li, YR,He, JL.

[3]Regulatory mutations in the A2M gene are involved in the mastitis susceptibility in dairy cows. Wang, X. G.,Huang, J. M.,Feng, M. Y.,Ju, Z. H.,Wang, C. F.,Zhong, J. F.,Yang, G. W.,Yuan, J. D.. 2014

[4]Variants and Gene Expression of the TLR2 Gene and Susceptibility to Mastitis in Cattle. Huang, Jinming,Liu, Li,Wang, Hongmei,Zhang, Cuixia,Ju, Zhihua,Wang, Changfa,Zhong, Jifeng.

[5]Molecular cloning, promoter analysis, SNP detection of Clusterin gene and their associations with mastitis in Chinese Holstein cows. Wang, Zeying,Wang, Genlin,Huang, Jingmin,Zhong, Jifeng.

[6]The expression patterns of DNA methylation reprogramming related genes are associated with the developmental competence of cloned embryos after zygotic genome activation in pigs. Huan, Yanjun,Wang, Hongmei,He, Hongbin,Huan, Yanjun,Liu, Zhonghua,Wu, Zhanfeng,Zhang, Jiguang.

[7]Genetic Variation of EPAS1 Gene in Tibetan Pigs and Three Low-Altitude Pig Breeds in China. Dong Kun-zhe,Yao Na,Shu Guo-tao,Zhao Qian-jun,Ma Yue-hui,Kang Ye,Zuo Qing-qing. 2014

[8]Subcellular localization, expression patterns, SNPs and association analyses of the porcine HUMMLC2B gene. Wang, Huan L.,Wang, Heng,Zhu, Zheng M.,Wang, Chen F.,Zhu, Meng J.,Mo, De L.,Yang, Shu L.,Li, Kui.

[9]HSF IS THE MOST IMPORTANT TRANSCRIPTIONAL FACTOR FOR PORCINE MC4R PROMOTER. Zhang, D. J.,Liu, D.,Wang, L.,Zhang, X. H.,Bie, S.. 2012

[10]Identification of the promoter region and genetic mutations of the porcine GALP gene. Su, Lina,Tao, Hu,Sun, Xiaojie,Zhang, Xuying,Li, Fenge,Su, Lina,Tao, Hu,Sun, Xiaojie,Zhang, Xuying,Li, Fenge,Mei, Shuqi,Peng, Xianwen,Wu, Huayu,Qiao, Mu,Li, Fenge.

[11]Molecular characterization, transcriptional regulation and association analysis with carcass traits of porcine TCAP gene. Qiao, Mu,Wu, Huayu,Wu, Junjing,Peng, Xianwen,Mei, Shuqi,Huang, Jingshu.

[12]DNA polymorphisms of the Hu sheep melanocortin-4 receptor gene associated with birth weight and 45-day weaning weight. Song, X. M.,Jiang, J. F.,Zhang, G. Z.,Jiang, Y. Q.,Zhang, G. Z.,Shi, F. X.. 2012

[13]POLYMORPHISMS OF THE MYOSTATIN GENE AND ITS RELATIONSHIP WITH REPRODUCTION TRAITS IN THE BIAN CHICKEN. Zhang, Genxi,Wei, Yue,Wang, Jinyu,Dai, Guojun,Xie, Kaizhou,Zhang, Li,Ding, Fuxiang. 2012

[14]Effect of an exon 1 mutation in the myostatin gene on the growth traits of the Bian chicken. Zhang, G. X.,Zhao, X. H.,Wang, J. Y.,Ding, F. X.,Zhang, L.. 2012

[15]Polymorphism in Exons of the Myostatin Gene and Its Relationship with Body Weight Traits in the Bian Chicken. Zhang, Genxi,Wang, Jinyu,Dai, Guojun,Xie, Kaizhou,Wang, Wei,Ding, Fuxiang,Zhang, Lijun,Zhou, Shenghua. 2011

[16]Polymorphisms in the myostatin gene and their association with growth and carcass traits in duck. Lu, Junqing,Hou, Shuisheng,Huang, Wei,Yu, Junying,Wang, Wenwu. 2011

[17]A R2R3 MYB transcription factor from ash positively regulates salt response in tobacco. Li, Tian,Sun, Jingkuan,Li, Tian,Bi, Yuping. 2017

[18]The cloning and sequencing of a cDNA encoding a WD repeat protein in cotton (Gossypium hirsutum L.). HONG Y. DUAN,FU G. LI,XU D. WU,DONG M. MA,MAO WANG,YU X. HOU.

[19]DNA-Bound peptides control the mRNA transcription through CDK7. Lv, Xiaowen,Lv, Feijie,Qin, Yuchang,Wang, Jing,Dong, Zhiyuan. 2009

[20]Structure and transcription of the Helicoverpa armigera densovirus (HaDV2) genome and its expression strategy in LD652 cells. Wu, Kongming,Xu, Pengjun,Graham, Robert I.,Wilson, Kenneth. 2017

作者其他论文 更多>>

微信小程序