Analysis of genetic variations of a recombinant strain derived from the three lineages of porcine reproductive and respiratory syndrome virus-2

文献类型： 外文期刊

第一作者： Zheng, Limei

作者： Zheng, Limei;Ma, Yingru;Wen, Jianxin;Li, Jun;Han, Xianjie;Wu, Xiaoyan;Liu, Chang;Li, Chen;Shi, Jianli;Han, Hong;Xu, Shaojian;Hrabchenko, Nataliia;Li, Jun;Huang, Mengjie;Qiu, Jianhua

作者机构： Qingdao Agr Univ, Qingdao, Peoples R China;Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Prov Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China;Shandong Agr Univ, Coll Anim Sci & Vet Med, Jinan, Peoples R China

关键词： PRRSV; recombination strains; GP5; NSP2; genetic evolutionary analysis; next-generation sequencing

期刊名称：VETERINARSKI ARHIV （ 2022影响因子：0.5； 五年影响因子：0.6 ）

ISSN： 0372-5480

年卷期： 2024 年 94 卷 3 期

页码：

收录情况： SCI

摘要： Since the rise of the porcine reproductive and respiratory syndrome virus (PRRSV) in China, gene mutations have frequently occurred. To understand the current prevalence and evolution of PRRSV in Shandong Province, 1,528 samples suspected of PRRSV were collected from local pig farms of different sizes. The complete genome sequence of the PRRSV strain SDLY-27 was determined by next-generation sequencing (NGS) technology. The genomic sequence of SDLY-27 was 15,363 nucleotides (nt) in length, comparative analysis of the whole genome sequence suggested that the homology between SDLY 27 and 81 PRRSV strains from China and other countries in genbank was 61.9 similar to 96.4%. This study is the first to detect recombinants from multiple recombination events among the Lineage 8 (JXA1-like strains), Lineage 5 (RespPRRSV-MLV and VR2332 strains) and Sublineage 1.5 (NADC34-like strains) in Shandong, China, and provides new data for the epidemiological study of PRRSV in China. This study enriches the epidemiological data on PRRSV in Shandong Province, China. It provides an important reference for the development of new vaccines and for the prevention and control of PRRSV in China.

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