POLYMORPHISMS OF THE MYOSTATIN GENE AND ITS RELATIONSHIP WITH REPRODUCTION TRAITS IN THE BIAN CHICKEN

文献类型： 外文期刊

第一作者： Zhang, Genxi

作者： Zhang, Genxi;Wei, Yue;Wang, Jinyu;Dai, Guojun;Xie, Kaizhou;Zhang, Li;Ding, Fuxiang

作者机构：

关键词： Bian chicken;Myostatin gene;Polymorphsims;Reproduction traits

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

年卷期： 2012 年 23 卷 3 期

页码：

收录情况： SCI

摘要： Myostatin, or growth and differentiation factor 8, is a member of the transforming growth factor-beta superfamily; it functions as a negative regulator of skeletal muscle development and growth in mammals. In this study, single nucleotide polymorphisms in the 5' regulatory region and exon 1 of the myostatin gene were detected by PCR-SSCP in the Bian, Jinghai, Youxi, and Arbor Acre chickens, and the associations of the polymorphisms with reproduction traits were analyzed. Seven SNPs (A326G, C334G, C1346T, G1375A, A1473G, G1491A, and G2283A) were found in the myostatin gene. Association analysis showed that the G2283A were significantly associated with reproduction traits. Bian chickens of the GG genotype had a greater age at first egg than those of the GA and AA genotypes (P < 0.01). Correspondingly, Bian chickens of the GA and AA genotypes had larger egg number at 300 days than those of the GG genotype (P < 0.05 and P < 0.01, respectively). Bian chickens of the AA genotype had significantly higher body weight at 300 days than those of the GG genotype (P < 0.05). These results suggested that the myostatin gene may have certain effects on reproduction traits other than merely as a negative regulator of skeletal muscle development and growth in mammals previously reported.

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