Effects of sulfur dioxide on expressions of p53, bax and bcl-2 in lungs of asthmatic rats
文献类型: 外文期刊
第一作者: Xie, Jingfang
作者: Xie, Jingfang;Li, Ruijin;Meng, Ziqiang;Xie, Jingfang;Fan, Renjun
作者机构:
关键词: sulfur dioxide;asthmatic rats;lungs;bax;bcl-2;p53
期刊名称:INHALATION TOXICOLOGY ( 影响因子:2.724; 五年影响因子:2.55 )
ISSN: 0895-8378
年卷期: 2009 年 21 卷 8-11 期
页码:
收录情况: SCI
摘要: Inhibition of cell apoptosis is an increasingly important factor in modulating airway inflammation in asthma, which is related to environmental pollutants. To investigate the effects of sulfur dioxide (SO2) on the mRNA and protein expressions of apoptosis-related genes in lungs from asthmatic rats, male Wistar rats were challenged by ovalbumin (OVA) or SO2 (2 ppm) inhalation alone or together. Examinations were performed 24 h after the last treatment. The mRNA and protein levels of p53, bax, and bcl-2 were analyzed in lungs using real-time reverse transcription-polymerase chain reaction (RTPCR) assay and Western blot analysis, respectively. The results indicated that increases of bcl-2 or decreases of p53 and bax mRNA and protein levels were not significant in lungs of rats exposed to SO2 alone, compared with controls, but elevated or reduced levels of these genes appeared in lungs of asthmatic rats exposed to SO2 plus OVA, compared with controls, suggesting that SO2 exposure could result in OVA-induced increases or decreases of transcription and translation levels of these apoptosis-related genes in rat lungs, and may have relations to airway inflammation in asthma. The regulation mechanism of apoptosis in asthma disease exposure to SO2 needs further study.
分类号:
- 相关文献
作者其他论文 更多>>
-
Target gene selection for sprayable dsRNA-based biopesticide against Tetranychus urticae Koch (Acari: Tetranychidae)
作者:Wang, Yifei;Duan, Yuanpeng;Liu, Meibin;Ren, Meifeng;Gao, Yue;Liu, Zhongfang;Zhang, Pengjiu;He, Lifei;Fan, Renjun;Yang, Jing;Zhou, Xuguo
关键词:
Tetranychus urticae ; molecular target; egg-soaking method; dsRNA-based biopesticides; spray-induced gene silencing -
Interface Reconstruction Driven by Lesion Effects: The Synergistic Mechanism of Surfactant Self-Assembly in Pesticide Droplet Deposition
作者:He, Lifei;Zhang, Guocai;Kong, Xianhao;Zhang, Pengjiu;Liu, Zhongfang;Yang, Jing;Fan, Renjun;Gao, Yue;He, Falin
关键词:interfacialheterogeneity; lesion effect; nonionicsurfactants; self-assembly; force balance model
-
Chromosome-level genome assembly of hawthorn spider mite, Amphitetranychus viennensis (Acari: Tetranychidae)
作者:Ren, Meifeng;Zhang, Yuying;Wang, Yifei;Duan, Yuanpeng;Gao, Yue;Liu, Zhongfang;Zhang, Pengjiu;He, Lifei;Fan, Renjun;Yang, Jing;Zhou, Xuguo
关键词:
-
Molecular target for sprayable double-stranded RNA-based biopesticide against Amphitetranychus viennensis (Acari, Tetranychidae)
作者:Duan, Yuanpeng;Wang, Yifei;Yang, Fan;Gao, Yue;Liu, Zhongfang;Zhang, Pengjiu;Lu, Junjiao;Fan, Renjun;Yang, Jing;Ren, Meifeng;Zhou, Xuguo
关键词:Target gene screening; Sprayable dsRNA-based biopesticide; Spray-induced gene silencing; Proteasome subunit beta 5; Spider mites; Amphitetranychus viennensis
-
The development of an egg-soaking method for delivering dsRNAs into spider mites
作者:Yang, Jing;Zhang, Yuying;Zhang, Zhonghuan;Ren, Meifeng;Wang, Yifei;Duan, Yuanpeng;Gao, Yue;Liu, Zhongfang;Zhang, Pengjiu;Fan, Renjun;Zhou, Xuguo
关键词:dsRNA delivery; Egg-soaking RNAi method; Sprayable RNAi biopesticide; Spider mites; Amphitetranychus viennensis; Tetranychus urticae
-
Target gene selection for RNAi-based biopesticides against the hawthorn spider mite, Amphitetranychus viennensis (Acari: Tetranychidae)
作者:Yang, Jing;Zhang, Yuying;Gao, Yue;Liu, Zhongfang;Zhang, Pengjiu;Fan, Renjun;Zhang, Yuying;Zhao, Jin;Xing, Shuping;Zhou, Xuguo;Fan, Renjun;Xing, Shuping;Zhou, Xuguo
关键词:dsRNA delivery; leaf disc-mediated RNAi; biopesticide target genes; mites
-
Vegetation structural shift tells environmental changes on the Tibetan Plateau over 40 years
作者:Wang, Yanfen;Xue, Kai;Hu, Ronghai;Ding, Boyang;Zeng, Hong;Pang, Zhe;Song, Xiaoning;Du, Jianqing;Zhang, Yangjian;Yu, Guirui;Wang, Yanfen;Xue, Kai;Hu, Ronghai;Song, Xiaoning;Du, Jianqing;Hao, Yanbin;Cui, Xiaoyong;Wang, Yanfen;Sun, Jian;Jiang, Lili;Wang, Shiping;Piao, Shilong;Xue, Kai;Zhao, Xinquan;Xue, Kai;Zhou, Huakun;Luo, Caiyun;Zhang, Zhenhua;Gao, Qingbo;Chen, Shilong;Li, Qi;Zhao, Liang;Xu, Shixiao;Hu, Linyong;Yang, Qien;Xue, Kai;Li, Ruijin;Xu, Bin;Li, Congjia;Zhang, Zelin;Hao, Yanbin;Cui, Xiaoyong;Guo, Ke;Yang, Xiuchun;Li, Yaoming;Ji, Baoming;Liu, Yali;Dong, Shikui;Guo, Ke;Gao, Qingzhu;Wu, Jianshuang;Gao, Qingzhu;Zhang, Yangjian;Zhu, Juntao;Xu, Xingliang;Yu, Guirui;Chen, Huai;Chen, Huai;Chen, Huai;Wu, Jianshuang;Wu, Jianshuang;Yang, Qien;He, Jinsheng;He, Jinsheng;Piao, Shilong;Fu, Bojie
关键词:Vegetation structural shift; Climate change; The Tibetan Plateau; Vegetation map