A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing

文献类型： 外文期刊

第一作者： Lan, Guangqian

作者： Lan, Guangqian;Ran, Luoxiao;Yu, Kun;Lu, Bitao;Dai, Fangying;Wu, Dayang;Lu, Fei;Lan, Guangqian;Dai, Fangying;Wu, Dayang;Lu, Fei;Xiao, Yang

作者机构：

关键词： Konjac glucomannan;Silver nanoparticle;Wound dressing;Antibacterial activity;Cytocompatibility;Wound healing

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2018 年 183 卷

页码：

收录情况： SCI

摘要： A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms. In vitro cytocompatibility testing showed that L929 cells could survive well in the presence of KGM/AgNPs, indicating that KGM/AgNPs have good cytocompatibility. Animal models showed that the KGM/AgNP composite sponges effectively accelerated wound healing, and histological findings showed that they promoted fibroblast growth and accelerated epithelialization. The experimental results showed that KGM/AgNP composite sponges have great potential in promoting wound healing.

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