A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E

文献类型: 外文期刊

第一作者: Chen, WeiGuo

作者: Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Li, Aijun;Shu, Dingming;Zhang, Huanmin;Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Chen, WeiGuo;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei

作者机构:

关键词: avian leukosis virus;tvb receptor gene;premature stop codon;host resistance;chicken

期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )

ISSN: 1949-2553

年卷期: 2017 年 8 卷 62 期

页码:

收录情况: SCI

摘要: Avian leukosis virus (ALV) is an oncogenic virus causing a variety of neoplasms in chickens. The group of avian leukosis virus in chickens contains six closely related subgroups, A to E and J. The prevalence of ALVs in hosts may have imposed strong selective pressure toward resistance to ALVs infection. The tvb gene encodes Tvb receptor and determines susceptibility or resistance to the subgroups B, D, and E ALV. In this study, we characterized a novel resistant allele of the tvb receptor gene, tvbr(3), which carries a single-nucleotide substitution (c.298C>T) that constitutes a premature termination codon within the fourth exon and leads to the production of a truncated TvbR3 receptor protein. As a result, we observed decreased susceptibility to infection by ALV-B, ALV-D and ALV-E both in vitro and in vivo, and decreased the binding affinity of the TvbR3 receptor for the subgroups B, D, and E ALV envelope glycoproteins. Additionally, we found that the tvbr3 allele was prevalent in Chinese broiler lines. This study demonstrated that premature termination codon in the tvb receptor gene can confer genetic resistance to subgroups B, D, and E ALV in the host, and indicates that tvbr3 could potentially serve as a resistant target against ALV-B, ALV-D and ALV-E infection.

分类号:

  • 相关文献

[1]Single nucleotide polymorphism variants within tva and tvb receptor genes in Chinese chickens. Liao, C. T.,Chen, S. Y.,Chen, W. G.,Liu, Y.,Sun, B. L.,Li, H. X.,Xie, Q. M.,Liao, C. T.,Xie, Q. M.,Zhang, H. M.,Qu, H.,Wang, J.,Shu, D. M.,Xie, Q. M..

[2]Expression and relationships of resistance to white rust (Albugo candida) at cotyledonary, seedling, and. flowering stages in Brassica juncea germplasm from Australia, China, and India. Li, C. X.,Sivasithamparam, K.,Walton, G.,Salisbury, P.,Burton, W.,Banga, Surinder S.,Banga, Shashi,Chattopadhyay, C.,Kumar, A.,Singh, R.,Singh, D.,Agnohotri, A.,Liu, S. Y.,Li, Y. C.,Fu, T. D.,Wang, Y. F.,Barbetti, M. J.. 2007

[3]Enhancing Fusarium crown rot resistance by pyramiding large-effect QTL in common wheat (Triticum aestivum L.). Zheng, Zhi,Gao, Shang,Liu, Chunji,Zheng, Zhi,Zheng, Zhi,Yan, Guijun,Liu, Chunji,Gao, Shang,Zhou, Meixue,Gao, Shang,Zhou, Meixue.

[4]Analysis of genome expression in the response of Oryza granulata to Xanthomonas oryzae pv oryzae. Lv, Guang-Lei,Wu, Wen-Ting,Cheng, Zai-Quan,Luo, Yu,Chen, Shan-Na.

[5]QTLs conferring FOV 7 resistance detected by linkage and association mapping in Upland cotton. Ning, Zhiyuan,Zhang, Tianzhen,Mei, Hongxian,Ai, Nijiang,Zhang, Xin.

[6]Development of an antigen-capture ELISA for the detection of avian leukosis virus p27 antigen. Yun, Bingling,Li, Delong,Zhu, Haibo,Liu, Wen,Qin, Liting,Liu, Zaisi,Wu, Guan,Wang, Yongqiang,Qi, Xiaole,Gao, Honglei,Wang, Xiaomei,Gao, Yulong. 2013

[7]Identification of a linear B-cell epitope on the avian leukosis virus P27 protein using monoclonal antibodies. Li, Xiaofei,Qi, Xiaole,Wang, Yongqiang,Gao, Honglei,Gao, Yulong,Wang, Xiaomei,Li, Xiaofei,Qin, Liting,Sun, Yingjun,Cui, Xuezhi,Gao, Yadong,Zhu, Haibo.

[8]16S rRNA genes Illumina sequencing revealed differential cecal microbiome in specific pathogen free chickens infected with different subgroup of avian leukosis viruses. Ma, Xinxin,Xu, Chuantian,Cui, Ning,Ma, Xinxin,Wang, Qi,Li, Hongmei,Xu, Chuantian,Cui, Ning,Zhao, Xiaomin.

[9]Gene expression changes in chicken NLRC5 signal pathway associated with in vitro avian leukosis virus subgroup J infection. Qiu, L. L.,Xu, L.,Guo, X. M.,Li, Z. T.,Wan, F.,Chen, G. H.,Chang, G. B.,Liu, X. P.. 2016

[10]Avian leukosis virus subgroup A and B infection in wild birds of Northeast China. Li, Delong,Qin, Liting,Qi, Xiaole,Wang, Yongqiang,Wang, Xiaomei,Gao, Yulong,Li, Delong,Liu, Sidang,Gao, Honglei,Yang, Bo,Liu, Wansi,Zeng, Xiangwei.

[11]Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers. Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan. 2015

[12]Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China. Zhang, Teng,Zhang, Teng,Jin, Qianyue,Ding, Peiyang,Chai, Yongxiao,Li, Yafei,Liu, Xiao,Luo, Jun,Zhang, Gaiping,Chai, Yongxiao,Liu, Xiao,Zhang, Gaiping,Ding, Peiyang,Li, Yafei,Wang, Yinbiao,Jin, Qianyue,Zhang, Gaiping. 2016

[13]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[14]An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens. Shu, D. M.. 2014

[15]Differentially expressed genes in the liver of lean and fat chickens. He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Li, H.,Wang, Q. G.. 2014

[16]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[17]Biological Characteristics of Chinese Precocious Strain of Eimeria acervulina and Its Immune Efficacy Against Different Field Strains. Wu, Lin-Lin,Lin, Rui-Qing,Duan, Wen-Fang,Zou, Shang-Shu,Yuan, Zi-Guo,Weng, Ya-Biao,Sun, Ming-Fei,Liu, Li-Dan. 2014

[18]Determination of virginiamycin M1 residue in tissues of swine and chicken by ultra-performance liquid chromatography tandem mass spectrometry. Wang, Xiaoyang,Wang, Mi,Zhang, Keyu,Hou, Ting,Zhang, Lifang,Fei, Chenzong,Xue, Feiqun,Wang, Xiaoyang,Hang, Taijun. 2018

[19]Up-regulation of NLRC5 and NF-kappa B signaling pathway in carrier chickens challenged with Salmonella enterica Serovar Pullorum at different persistence periods. Liu, Xiangping,Sheng, Zhongwei,Dou, Xinhong,Wang, Kehua,Ma, Teng,Wang, Hongzhi,Li, Zhiteng,Pan, Zhiming,Chang, Guobin,Chen, Guohong. 2015

[20]Dissection of Myogenic Differentiation Signatures in Chickens by RNA-Seq Analysis. Li, Tingting,Zhang, Genxi,Wu, Pengfei,Liu, Qiuhong,Wang, Jinyu,Duan, Lian,Li, Guohui. 2018

作者其他论文 更多>>