A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E
文献类型: 外文期刊
第一作者: Chen, WeiGuo
作者: Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Li, Aijun;Shu, Dingming;Zhang, Huanmin;Chen, WeiGuo;Liu, Yang;Li, Xinjian;Li, Hongxing;Dai, Zhenkai;Yan, Yiming;Zhang, Xinheng;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei;Chen, WeiGuo;Lin, Wencheng;Ma, Jingyun;Xie, Qingmei
作者机构:
关键词: avian leukosis virus;tvb receptor gene;premature stop codon;host resistance;chicken
期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )
ISSN: 1949-2553
年卷期: 2017 年 8 卷 62 期
页码:
收录情况: SCI
摘要: Avian leukosis virus (ALV) is an oncogenic virus causing a variety of neoplasms in chickens. The group of avian leukosis virus in chickens contains six closely related subgroups, A to E and J. The prevalence of ALVs in hosts may have imposed strong selective pressure toward resistance to ALVs infection. The tvb gene encodes Tvb receptor and determines susceptibility or resistance to the subgroups B, D, and E ALV. In this study, we characterized a novel resistant allele of the tvb receptor gene, tvbr(3), which carries a single-nucleotide substitution (c.298C>T) that constitutes a premature termination codon within the fourth exon and leads to the production of a truncated TvbR3 receptor protein. As a result, we observed decreased susceptibility to infection by ALV-B, ALV-D and ALV-E both in vitro and in vivo, and decreased the binding affinity of the TvbR3 receptor for the subgroups B, D, and E ALV envelope glycoproteins. Additionally, we found that the tvbr3 allele was prevalent in Chinese broiler lines. This study demonstrated that premature termination codon in the tvb receptor gene can confer genetic resistance to subgroups B, D, and E ALV in the host, and indicates that tvbr3 could potentially serve as a resistant target against ALV-B, ALV-D and ALV-E infection.
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