Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59

文献类型： 外文期刊

第一作者： Zhang, Yang-Mei

作者： Zhang, Yang-Mei;Liu, Bai-Lian;Zheng, Xin-Heng;Huang, Xiao-Jun;Li, Hong-Yu;Zhang, Ying;Zhang, Ting-Ting;Zhou, Guang-Xiong;Sun, Da-Yuan;Lin, Bi-Run

作者机构：

关键词： Streptomyces anandii;anandins A and B;steroidal alkaloids;cytotoxicity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2017 年 15 卷 11 期

页码：

收录情况： SCI

摘要： Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 g/mL, respectively.

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