The dynamic landscape of gene regulation during Bombyx mori oogenesis

文献类型： 外文期刊

第一作者： Zhang, Qiang

作者： Zhang, Qiang;Sun, Wei;Sun, Bang-Yong;Zhang, Ze;Xiao, Yang;Zhang, Ze

作者机构：

关键词： Bombyx mori;Oogenesis;Gene regulation;Ecdysteroid biosynthesis;Co-expression network;Transcription factors

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2017 年 18 卷

页码：

收录情况： SCI

摘要： Background: Oogenesis in the domestic silkworm (Bombyx mori) is a complex process involving previtellogenesis, vitellogenesis and choriogenesis. During this process, follicles show drastic morphological and physiological changes. However, the genome-wide regulatory profiles of gene expression during oogenesis remain to be determined. Results: In this study, we obtained time-series transcriptome data and used these data to reveal the dynamic landscape of gene regulation during oogenesis. A total of 1932 genes were identified to be differentially expressed among different stages, most of which occurred during the transition from late vitellogenesis to early choriogenesis. Using weighted gene co-expression network analysis, we identified six stage-specific gene modules that correspond to multiple regulatory pathways. Strikingly, the biosynthesis pathway of the molting hormone 20-hydroxyecdysone (20E) was enriched in one of the modules. Further analysis showed that the ecdysteroid 20-hydroxylase gene (CYP314A1) of steroidgenesis genes was mainly expressed in previtellogenesis and early vitellogenesis. However, the 20E-inactivated genes, particularly the ecdysteroid 26-hydroxylase encoding gene (Cyp18a1), were highly expressed in late vitellogenesis. These distinct expression patterns between 20E synthesis and catabolism-related genes might ensure the rapid decline of the hormone titer at the transition point from vitellogenesis to choriogenesis. In addition, we compared landscapes of gene regulation between silkworm (Lepidoptera) and fruit fly (Diptera) oogeneses. Our results show that there is some consensus in the modules of gene co-expression during oogenesis in these insects. Conclusions: The data presented in this study provide new insights into the regulatory mechanisms underlying oogenesis in insects with polytrophic meroistic ovaries. The results also provide clues for further investigating the roles of epigenetic reconfiguration and circadian rhythm in insect oogenesis.

分类号：

  • 相关文献

[1]Proteome analysis of silkworm, bombyx mori, larval gonads: Characterization of proteins involved in sexual dimorphism and gametogenesis. Chen, Jin-e,Li, Jian-ying,You, Zheng-ying,Jiang, Zhen-dong,Zhong, Bo-xiong,Chen, Jin-e,Li, Jian-ying,Liu, Li-li,Chen, Ming,Liang, Jian-she,Ma, Ying-ying,Zhang, Hua-rong.

[2]Identification of a POU factor involved in regulating the neuron-specific expression of the gene encoding diapause hormone and pheromone biosynthesis-activating neuropeptide in Bombyx mori. Zhang, TY,Kang, L,Zhang, ZF,Xu, WH.

[3]Molecular cloning and characterization of Bombyx mori CREB gene. Song, Hongsheng,Sun, Yue,Zhang, Yang,Li, Muwang.

[4]Comparative transcriptome sequencing of tolerant rice introgression line and its parents in response to drought stress. Huang, Liyu,Zhang, Fan,Zhang, Fan,Wang, Wensheng,Zhou, Yongli,Fu, Binying,Li, Zhikang,Zhang, Fan. 2014

[5]Identification and Functional Analysis of Chitin Synthase A in Oriental Armyworm, Mythimna separata. Zhai, Yifan,Yin, Zhenjuan,Men, Xingyuan,Zheng, Li,Zhai, Yifan,Fan, Xiaobin,Yue, Xiangzhao,Zhang, Wenqing,Zhai, Yifan,Fan, Xiaobin,Yue, Xiangzhao,Zhang, Wenqing. 2017

[6]Expression analysis and characterization of an autosome-localized tesk1 gene in half-smooth tongue sole (Cynoglossus semilaevis). Xu, Wenteng,Li, Hailong,Zhang, Ning,Dong, Zhongdian,Wang, Na,Shao, Changwei,Chen, Songlin,Xu, Wenteng,Li, Hailong,Zhang, Ning,Dong, Zhongdian,Wang, Na,Shao, Changwei,Chen, Songlin.

[7]cDNA cloning and expression of Ubc9 in the developing embryo and ovary of oriental river prawn, Macrobrachium nipponense. Zhang, Fengying,Chen, Liqiao,Wu, Ping,Zhao, Weihong,Li, Erchao,Zhang, Fengying,Qin, Jianguang.

[8]Characterization of a novel nm23 gene and its potential roles in gametogenesis in the prawn Macrobrachium rosenbergii (de Man, 1879) (Crustacea: Decapoda). Song, Ya-Nan,Lu, Cui-Yun,Chen, Jie,Qiu, Gao-Feng,Lu, Cui-Yun.

[9]Oogenesis in the Bemisia tabaci MEAM1 species complex. Ye, Gong-Yin,Guo, Jian-Yang,Wan, Fang-Hao. 2016

[10]Effects of Periodically Repeated Heat Events on Reproduction and Ovary Development of Agasicles hygrophila (Coleoptera: Chrysomelidae). Wang, Yao,Zhou, Zhong-Shi,Wang, Ren,Guo, Jian-Ying,Wan, Fang-Hao,Wan, Fang-Hao.

[11]Characteristics of Cyclin B and its potential role in regulating oogenesis in the red claw crayfish (Cherax quadricarinatus). Wang, L. M.,Dong, Z. J.,Wang, L. M.,Lv, W. W.,Zuo, D.,Zhao, Y. L.. 2015

[12]In rice, Oryzalin and abscisic acid differentially affect tubulin mRNA and protein levels. Giani, S,Qin, XQ,Faoro, F,Breviario, D. 1998

[13]Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential. Miao Xiang-yang. 2017

[14]The PP2A-A beta Gene is Regulated by Multiple Transcriptional Factors Including Ets-1, SP1/SP3, and RXR alpha/beta. Liu, J.,Chen, P. -C.,Hu, W. -F.,Hu, X.,Liu, W. -B.,Xiao, Y. -M.,Liang, S. -P.,Liu, Y.,Liu, S. -J.,Li, D. W. -C.,Liu, J.,Ji, W.,Sun, S.,Zhang, L.,Chen, H. -G.,Zhang, X.,Gong, L.,Deng, M.,Chen, P. -C.,Hu, W. -F.,Hu, X.,Liu, J.,Woodward, Z.,Li, D. W. -C.,Li, D. W. -C.,Liu, J.,Sun, S.,Zhang, L.,Chen, H. -G.,Mao, Y.,Liu, L.,Gong, L.,Deng, M.,Deng, M.,Chen, L.,Han, W. -J.. 2012

[15]Isolation and Characterization of a Stress-Dependent Plastidial Delta(12) Fatty Acid Desaturase from the Antarctic Microalga Chlorella vulgaris NJ-7. Lu, Yandu,Qin, Song,Lu, Yandu,Li, Fuchao,Liu, Shaofang,Lu, Yandu,Liu, Shaofang,Chi, Xiaoyuan,Yang, Qingli,Li, Zhaoxin,Gan, Qinhua. 2010

[16]Chilling acclimation provides immunity to stress by altering regulatory networks and inducing genes with protective functions in Cassava. Zeng, Changying,Chen, Xin,Zhou, Yufei,Bo, Weiping,Song, Shun,Deng, Deli,Guo, Xin,Wang, Bin,Wang, Wenquan,Peng, Ming,Chen, Zheng,Xia, Jing,Zhang, Kevin,Zhou, Junfei,Peng, Hai,Zhang, Weixiong,Chen, Zheng,Xia, Jing,Zhang, Kevin,Zhang, Weixiong,Zhang, Weixiong. 2014

[17]Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development. Chai, Guohua,Zhu, Ming,Yu, Li,Qi, Guang,Tang, Xianfeng,Wang, Zengguang,Cao, Yingping,Yu, Changjiang,Zhou, Gongke,Kong, Yingzhen.

[18]Global characterization of microRNAs in Trichomonas gallinae. Xu, Min-Jun,Qiu, Shen-Ben,Fu, Jing-Hua,Zhu, Xing-Quan,Nisbet, Alasdair J.,Qiu, Shen-Ben,Fu, Jing-Hua,Shao, Chang-Chun. 2014

[19]Functions and Application of the AP2/ERF Transcription Factor Family in Crop Improvement. Xu, Zhao-Shi,Chen, Ming,Li, Lian-Cheng,Ma, You-Zhi. 2011

[20]Down-regulation of the OsPDCD5 gene induced photoperiod-sensitive male sterility in rice. Wang, Yufeng,Zha, Xiaojun,Qian, Xiaoyin,Dong, Xianxin,Sun, Fan,Yang, Jinshui,Zhang, Shiyong. 2010

作者其他论文 更多>>

微信小程序