Differential gene expression and gut microbiota composition in low-altitude and high-altitude goats

文献类型： 外文期刊

第一作者： Zhang, Zhenzhen

作者： Zhang, Zhenzhen;Zhang, Xin;Li, Jingjing;Zhao, Wangsheng;Zhang, Tingting;Renqing, Cuomu;Song, Tianzeng;Renqing, Cuomu;Song, Tianzeng;Baijiu, Zhaxi;Baima, Sangzhu;Zhaxi, Wangjie;Nima, Yuzhen

作者机构：

关键词： Goat; Altitude; Gut microbiota; Testis; Reproductive fitness; Synergistic role

期刊名称：GENOMICS （ 影响因子：3.0； 五年影响因子：3.3 ）

ISSN： 0888-7543

年卷期： 2024 年 116 卷 5 期

页码：

收录情况： SCI

摘要： Previous studies have presented evidence suggesting that altitude exerts detrimental effects on reproductive processes, yet the underlying mechanism remains elusive. Our study employed two distinct goat breeds inhabiting low and high altitudes, and conducted a comparative analysis of mRNA profiles in testis tissues and the composition of gut microbiota. The results revealed a reduced testis size in high-altitude goats. RNA-seq analysis identified the presence of 214 differentially expressed genes (DEGs) in the testis. These DEGs resulted in a weakened immunosuppressive effect, ultimately impairing spermatogenesis in high-altitude goats. Additionally, 16S rDNA amplicon sequencing recognized statistically significant variations in the abundance of the genera Treponema, unidentified_Oscillospiraceae, Desulfovibrio, Butyricicoccus, Dorea, Parabacteroides between the two groups. The collective evidence demonstrated the gut and testis played a synergistic role in causing decreased fertility at high altitudes. Our research provides a theoretical basis for future investigations into the reproductive fitness of male goats.

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