Protective effect of Momordica charantia water extract against liver injury in restraint-stressed mice and the underlying mechanism

文献类型： 外文期刊

第一作者： Deng, Yuanyuan

作者： Deng, Yuanyuan;Tang, Qin;Zhang, Yan;Zhang, Ruifen;Wei, Zhencheng;Tang, Xiaojun;Zhang, Mingwei

作者机构：

关键词： Momordica charantia;restraint stress;liver function;antioxidation;mitochondria

期刊名称：FOOD & NUTRITION RESEARCH （ 影响因子：3.894； 五年影响因子：4.442 ）

ISSN： 1654-6628

年卷期： 2017 年 61 卷

页码：

收录情况： SCI

摘要： Background: Momordica charantia is used in China for its jianghuo (heat-clearing and detoxifying) effects. The concept of shanghuo (the antonym of jianghuo, excessive internal heat) in traditional Chinese medicine is considered a type of stress response of the body. The stress process involves internal organs, especially the liver. Objective: We hypothesized that Momordica charantia water extract (MWE) has a hepatoprotective effect and can protect the body from stress. The aim of this study was to investigate the possible effects of MWE against liver injury in restraint-stressed mice. Design: The mice were intragastrically administered with MWE (250, 500 and 750 mg/kg bw) daily for 7 days. The Normal Control (NC) and Model groups were administered distilled water. A positive control group was intragastrically administered vitamin C 250 mg/kg bw. After the last administration, mice were restrained for 20 h. Results: MWE reduced the serum AST and ALT, reduced the NO content and the protein expression level of iNOSin the liver; significantly reduced the mitochondrial ROS content, increased the mitochondrial membrane potential and the activities of mitochondrial respiratory chain complexes I and II in restraint-stressed mice. Conclusions: The results indicate that MWE has a protective effect against liver injury in restraintstressed mice.

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