INFLAMMATION-RELATED OXIDATIVE STRESS IN WHITE ADIPOSE TISSUES OF AN INBRED OBESE PIG

文献类型： 外文期刊

第一作者： Yang, X. F.

作者： Yang, X. F.;Jiang, Z. Y.;Tian, Z. M.;Qiu, Y. Q.;Wang, L.;Gao, K. G.;Hu, Y. J.;Ma, X. Y.

作者机构：

关键词： obese pig;adipose tissue;oxidative stress;LPS;inflammation

期刊名称：ANNALS OF ANIMAL SCIENCE （ 影响因子：2.09； 五年影响因子：2.103 ）

ISSN： 2300-8733

年卷期： 2017 年 17 卷 2 期

页码：

收录情况： SCI

摘要： The uneven development of adipose tissues reflects a differential occurrence of biological events in vivo while the underlying molecular mechanism remains largely unknown. In the present study, the in vivo inflammatory status of an inbred obese porcine model, Lantang pig, was assessed, aiming to provide evidence for obesity biology. Compared with genetically lean pigs (crossbred, Duroc x Landrace x Large White), Lantang pigs exhibited a larger amount of ultra large adipocytes in subcutaneous adipose tissue accompanied with higher expression of macrophage/monocytes markers and pro-inflammatory genes (TLR4, CD14, CD11 beta, MCP1, TNF alpha, IL1 beta and IL6) and lower expression of cellular antioxidant enzymes (SOD1, 2 and 3). Plasma concentrations of LPS and TNF-alpha were also higher in Lantang pigs than in lean pigs. Among adipose tissues of Lantang pigs, the subcutaneous tissue had the most abundant expression of inflammation related genes (TLR4, CD14, TNF alpha and IL6) and the lowest level of cellular antioxidant genes (SOD 1 and 2), while the perirenal adipose tissue had opposite profile. Significant activation of p38 MAPK pathway was indicated by increased phosphorylation of p38 in the subcutaneous adipose tissue of Lantang pigs. Collectively, the bacteria-derived LPS induced inflammation-associated oxidative stress indeed exists in adipose tissues of Lantang pig, and the differential expressions of inflammatory and antioxidant genes, to some extent, account for the uneven development of the adipose tissue within bodies.

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