Enantio-selective preparation of (S)-1-phenylethanol by a novel marine GDSL lipase MT6 with reverse stereo-selectivity

文献类型： 外文期刊

第一作者： Deng, Dun

作者： Deng, Dun;Zhang, Yun;Sun, Aijun;Hu, Yunfeng;Deng, Dun;Zhang, Yun;Sun, Aijun;Hu, Yunfeng;Deng, Dun;Hu, Yunfeng

作者机构：

关键词： GDSL lipase;Biocatalysis;Kinetic resolution;Direct hydrolysis;(S)-1-Phenylethanol;Reverse stereo-selectivity

期刊名称：CHINESE JOURNAL OF CATALYSIS （ 影响因子：8.271； 五年影响因子：5.923 ）

ISSN： 0253-9837

年卷期： 2016 年 37 卷 11 期

页码：

收录情况： SCI

摘要： We previously functionally characterized a novel marine microbial GDSL lipase MT6 and identified that the stereo-selectivity of MT6 was opposite to that of other common lipases in trans-esterification reactions. Herein, we have investigated the use of MT6 in stereo-selective biocatalysis through direct hydrolysis reactions. Notably, the stereo-selectivity of MT6 was also demonstrated to be opposite to that of other common lipases in hydrolysis reactions. Parameters, including temperature, organic co-solvents, pH, ionic strength, catalyst loading, substrate concentration, and reaction time, affecting the enzymatic resolution of racemic 1-phenylethyl acetate were further investigated, with the e.e. of the final (S)-1-Phenylethanol product and the conversion being 97% and 28.5%, respectively, after process optimization. The lengths of side chains of 1-phenylethyl esters greatly affected the stereo-selectivity and conversion during kinetic resolutions. MT6 is a novel marine microbial GDSL lipase exhibiting opposite stereo-selectivities than other common lipases in both trans-esterification reactions and hydrolysis reactions. (C) 2016, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

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