Genome-wide association study of aggressive behaviour in chicken

文献类型： 外文期刊

第一作者： Li, Zhenhui

作者： Li, Zhenhui;Zheng, Ming;Abdalla, Bahareldin Ali;Zhang, Zhe;Xu, Zhenqiang;Ye, Qiao;Xu, Haiping;Luo, Wei;Nie, Qinghua;Zhang, Xiquan;Li, Zhenhui;Zheng, Ming;Abdalla, Bahareldin Ali;Zhang, Zhe;Xu, Zhenqiang;Ye, Qiao;Xu, Haiping;Luo, Wei;Nie, Qinghua;Zhang, Xiquan;Li, Zhenhui;Zheng, Ming;Abdalla, Bahareldin Ali;Zhang, Zhe;Xu, Zhenqiang;Ye, Qiao;Xu, Haiping;Luo, Wei;Nie, Qinghua;Zhang, Xiquan;Xu, Zhenqiang

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： In the poultry industry, aggressive behaviour is a large animal welfare issue all over the world. To date, little is known about the underlying genetics of the aggressive behaviour. Here, we performed a genome-wide association study (GWAS) to explore the genetic mechanism associated with aggressive behaviour in chickens. The GWAS results showed that a total of 33 SNPs were associated with aggressive behaviour traits (P < 4.6E-6). rs312463697 on chromosome 4 was significantly associated with aggression (P = 2.10905E-07), and it was in the intron region of the sortilin-related VPS10 domain containing receptor 2 (SORCS2) gene. In addition, biological function analysis of the nearest 26 genes around the significant SNPs was performed with Ingenuity Pathway Analysis. An interaction network contained 17 genes was obtained and SORCS2 was involved in this network, interacted with nerve growth factor (NGF), nerve growth factor receptor (NGFR), dopa decarboxylase (L-dopa) and dopamine. After knockdown of SORCS2, the mRNA levels of NGF, L-dopa and dopamine receptor genes DRD1, DRD2, DRD3 and DRD4 were significantly decreased (P < 0.05). In summary, our data indicated that SORCS2 might play an important role in chicken aggressive behaviour through the regulation of dopaminergic pathways and NGF.

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