Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues

文献类型： 外文期刊

第一作者： Chen, Wei

作者： Chen, Wei;Ma, Xianyong;Lin, Yingcai;Xiong, Yunxia;Zheng, Chuntian;Hu, Youjun;Yu, Deqian;Jiang, Zongyong;Chen, Wei;Ma, Xianyong;Lin, Yingcai;Xiong, Yunxia;Zheng, Chuntian;Hu, Youjun;Yu, Deqian;Jiang, Zongyong;Chen, Wei;Ma, Xianyong;Lin, Yingcai;Xiong, Yunxia;Zheng, Chuntian;Hu, Youjun;Yu, Deqian;Jiang, Zongyong;Chen, Wei;Ma, Xianyong;Lin, Yingcai;Xiong, Yunxia;Zheng, Chuntian;Hu, Youjun;Yu, Deqian;Jiang, Zongyong;Chen, Wei;Ma, Xianyong;Lin, Yingcai;Xiong, Yunxia;Zheng, Chuntian;Hu, Youjun;Yu, Deqian;Jiang, Zongyong

作者机构：

关键词： Anti-/pro-oxidant enzyme;Daidzein;Fat;Liver;Muscle;Pigs

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 2049-1891

年卷期： 2016 年 7 卷

页码：

收录情况： SCI

摘要： Background: Although isoflavones are natural dietary antioxidants, they may have toxicological effects. This study aimed to evaluate the redox system in tissues of finishing pigs by supplementation with high dose of daidzein (640 mg/kg). Results: The supplementation of high dose of daidzein for 64 d increased the activity of superoxide dismutase and total antioxidant capacity in longissimus muscle but down-regulated the expression of reactive oxygen species (ROS)-producing enzyme NADPH oxidase-2 and cyclooxygenase-2. In contrast, high-level supplementation with daidzein exerted pro-oxidant changes in back fat, abdominal fat, liver, and plasma, as reflected by increased contents of malondialdehyde, a lipid peroxidation product, in these tissues. Furthermore, daidzein supplementation resulted in higher expression of ROS-producing enzymes, including NADPH oxidase-1 and cyclooxygenase-1 in liver, 5-lipoxygenase (5-LOX) in backfat and NADPH oxidase-2 both in abdominal fat and backfat. The supplementation of daidzein did not affect meat quality parameters in longissimus muscle, including marbling score, eye muscle areas, intramuscular fat, shear force, drip loss, pH and meat color. Conclusions: This experiment suggests that dietary supplementation of finishing pigs with daidzein at a high dose level improves redox status in muscle but exerts pro-oxidant effect in liver and fat tissues.

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