Host Innate Immune Responses of Ducks Infected with Newcastle Disease Viruses of Different Pathogenicities

文献类型： 外文期刊

第一作者： Kang, Yinfeng

作者： Kang, Yinfeng;Li, Yanling;Yuan, Runyu;Feng, Minsha;Xiang, Bin;Sun, Minhua;Li, Yaling;Xie, Peng;Tan, Yangtong;Ren, Tao;Kang, Yinfeng;Li, Yanling;Yuan, Runyu;Feng, Minsha;Xiang, Bin;Sun, Minhua;Li, Yaling;Xie, Peng;Tan, Yangtong;Ren, Tao;Kang, Yinfeng;Li, Yanling;Feng, Minsha;Xiang, Bin;Ren, Tao;Yuan, Runyu;Sun, Minhua

作者机构：

关键词： host innate immune responses;duck;lung;thymus;Newcastle disease virus

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2015 年 6 卷

页码：

收录情况： SCI

摘要： Though previous studies have identified two strains of duck-origin Newcastle disease virus (NDV) with varying levels of pathogenicity, the relationship between the early-phase host innate immune response, and pathogenesis of ducks infected with these strains in the lungs and thymuses remains unclear. In this study, we compared the viral distribution and mRNA expression of immune-related genes in ducks following infection with two NDV strains, Duck/CH/GD/SS/10 (SS-10) and Duck/CH/GD/NH/10 (NH-10). Both NDV strains replicated systemically in tested tissues (i.e., small intestine, cecal tonsils, brain, lung, bursa of Fabricius, thymus, and spleen) and exhibited different biological properties in duck pathogenicity. Real-time quantitative polymerase chain reaction showed that the expression of TLR3, TLR7, RIG-1, MDA5, IL-2, IL-6, IL-8, IFN-alpha, IFN-beta, IFN-gamma in the lungs was significantly greater than in the respective thymus genes during the early post infection stage. However, in the lungs, the expression of TLR3, TLR7, IL-beta, IL-2, IL-8, IFN-alpha, IFN-gamma, and MHC II induced by SS-10 at 72 h post-inoculation (hpi) was less than with NH-10. Furthermore, the expression of IL-6 and IFN-beta in the lungs and thymuses following infection with SS 10 was greater than that with NH-10 at 24 and 48 hpi. These results highlight important differences in host innate immune responses, courses of infection, and pathogenesis following NDV infection. Further studies should work to expand understandings of the molecular mechanisms related to NDV infection.

分类号：

  • 相关文献

[1]Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks. Cheng, Yuqiang,Wang, Hengan,Yan, Yaxian,Sun, Jianhe,Ding, Chan.

[2]Infectivity and Pathogenicity of Newcastle Disease Virus Strains of Different Avian Origin and Different Virulence for Mallard Ducklings. Dai, Yabin,Liu, Mei,Cheng, Xu,Shen, Xinyue,Wei, Yuyong,Zhou, Sheng,Yu, Shengqing,Ding, Chan. 2013

[3]Experimental infection of duck origin virulent Newcastle disease virus strain in ducks. Dai, Yabin,Cheng, Xu,Liu, Mei,Shen, Xinyue,Li, Jianmei,Zou, Jianmin,Dai, Yabin,Cheng, Xu,Liu, Mei,Shen, Xinyue,Li, Jianmei,Zou, Jianmin,Yu, Shengqing,Ding, Chan. 2014

[4]Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene. Cheng, Yuqiang,Wang, Hengan,Shi, Shuduan,Yan, Yaxian,Sun, Jianhe,Sun, Yingjie,Ding, Chan,Li, Jing.

[5]GROWTH PERFORMANCE AND ANTIOXIDANT CAPACITIES IN PIGLETS WITH DIFFERENT WEANING AGE. Li, L. A.,Yang, J. J.,Li, Y.,Jin, T. M.,Li, R. N.,Qin, S. Y.,Xie, J. J.,Du, G. M.. 2016

[6]Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus. Wang, Gang,He, Yuli,Tu, Yabin,Liu, Yonggang,Han, Zifeng,Jiang, Chenggang,Wang, Shujie,Shi, Wenda,Cai, Xuehui,Zhou, En-Min,Han, Zifeng. 2014

[7]Positive role for rApxIVN in the immune protection of pigs against infection by Actinobacillus pleuropneumoniae. Wang, Chunlai,Wang, Yong,Shao, Meili,Si, Wei,Liu, Huifang,Chang, Yuehong,Peng, Wei,Kong, Xiangang,Liu, Siguo,Shao, Meili.

[8]Expression of immunoproteasome subunits in the porcine lung: Alterations during normal and inflammatory conditions. Liu, Qiang,Zhang, Yong-Li,Hu, Shou-Ping,Ma, Ze-Lin,Gao, Su-Li,Sun, Bin,Xiao, Fei,Zhang, Zhuo,Cai, Xue-Hui,He, Xi-Jun.

[9]Influence of Longdan Xiegan Decoction on Body Weights and Immune Organ Indexes in Ducklings Intoxicated with Aflatoxin B-1. Guo, S. N.,Su, R. S.,Lin, R. Q.,Chen, Y. Z.,Tang, Z. X.,Shi, D. Y.,Wu, H.,Liao, S. Q.. 2012

[10]Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephelus akaara). Mao, Ming-Guang,Lei, Ji-Lin,Hong, Wan-Shu,Wang, Ke-Jian,Lei, Ji-Lin,Alex, Peralvarez-Marin. 2012

[11]Histology and ultrastructure of the thymus during development in tilapia, Oreochromis niloticus. Cao, Jianmeng,Chen, Qiong,Lu, Maixin,Hu, Xinxin,Wang, Miao,Chen, Qiong,Hu, Xinxin.

[12]Effects of Dietary Protein and Calcium on Thymus Apoptosis Induced by Fluoride in Female Rats (Wistar Rats). Wang, Hongwei,Zhou, Bianhua,Cao, Jinling,Cao, Chunfang,Wang, Jundong,Zhou, Bianhua,Gu, Xinli.

[13]Chimeric rabies glycoprotein with a transmembrane domain and cytoplasmic tail from Newcastle disease virus fusion protein incorporates into the Newcastle disease virion at reduced levels. Yu, Gui Mei,Zu, Shu Long,Zhou, Wei Wei,Wang, Xi Jun,Shuai, Lei,Wang, Xue Lian,Ge, Jin Ying,Bu, Zhi Gao. 2017

[14]Newcastle disease virus employs macropinocytosis and Rab5a-dependent intracellular trafficking to infect DF-1 cells. Tan, Lei,Zhang, Yuqiang,Zhan, Yuan,Yuan, Yanmei,Sun, Yingjie,Qiu, Xusheng,Meng, Chunchun,Song, Cuiping,Liao, Ying,Ding, Chan,Ding, Chan. 2016

[15]Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells. Meng, Gang,Xia, Mao,Wang, Diancheng,Chen, Aiping,Wang, Hongwei,Yu, Decai,Wei, Jiwu,Yu, Decai,Wei, Jiwu,Wang, Yongshan. 2014

[16]Immune Effect of Newcastle Disease Virus DNA Vaccine with C3d as a Molecular Adjuvant. Zhao, Kai,Duan, Xutong,Hao, Lianwei,Wang, Xiaohua,Zhao, Kai,Duan, Xutong,Wang, Yunfeng. 2017

[17]F gene recombination between genotype II and VII Newcastle disease virus. Sun, Lei,Zhu, Yiping,Kitamura, Yoshihiro,Liu, Wenjun,Qin, Zhuoming,Ma, Baochen,Cui, Zhizhong. 2008

[18]Recombinant infectious bursal disease virus expressing Newcastle disease virus (NDV) neutralizing epitope confers partial protection against virulent NDV challenge in chickens. Li, Kai,Gao, Li,Gao, Honglei,Qi, Xiaole,Gao, Yulong,Qin, Liting,Wang, Yongqiang,Wang, Xiaomei.

[19]Newcastle disease virus-like particles induce dendritic cell maturation and enhance viral-specific immune response. Qian, Jing,Ding, Jiaxin,Yin, Renfu,Xue, Cong,Xu, Xiaohong,Cong, Yanlong,Ding, Zhuang,Qian, Jing,Ding, Jiaxin,Yin, Renfu,Xue, Cong,Xu, Xiaohong,Cong, Yanlong,Ding, Zhuang,Sun, Yixue,Wang, Jianzhong,Ding, Chan,Yu, Shengqing,Liu, Xiufan,Hu, Shunlin.

[20]Genetic variation in V gene of class II Newcastle disease virus. Hao, Huafang,Liu, Peng,Ren, Shanhui,Gao, Xiaolong,Wang, Yanping,Wang, Xinglong,Zhang, Shixia,Yang, Zengqi,Chen, Shengli.

作者其他论文 更多>>

微信小程序