Oleate promotes differentiation of chicken primary preadipocytes in vitro

文献类型： 外文期刊

第一作者： Shang, Zhouchun

作者： Shang, Zhouchun;Guo, Lin;Wang, Ning;Shi, Hui;Wang, Yuxiang;Li, Hui;Shang, Zhouchun;Guo, Lin;Wang, Ning;Shi, Hui;Wang, Yuxiang;Li, Hui;Shang, Zhouchun;Guo, Lin;Wang, Ning;Shi, Hui;Wang, Yuxiang;Li, Hui

作者机构：

关键词： adipogenesis;chicken;differentiation;fatty acid;inducer;preadipocyte

期刊名称：BIOSCIENCE REPORTS （ 影响因子：3.84； 五年影响因子：4.059 ）

ISSN： 0144-8463

年卷期： 2014 年 34 卷

页码：

收录情况： SCI

摘要： In addition to providing energy and constituting cell membrane, fatty acids also play an important role in adipocyte differentiation and lipid metabolism. As an important member of monounsaturated fatty acids, oleate, together with other components, is widely used to induce chicken preadipocyte differentiation. However, it is not clear whether oleate alone can induce chicken preadipocyte differentiation. In the present study, four different treatments were designed to test this question: basal medium, IDX [insulin, dexamethasone and IBMX (isobutylmethylxanthine)], oleate and IDX plus oleate. Cytoplasmic lipid droplet accumulation and mRNA expression for adipogenesis-related genes were monitored. After treatment of oleate on chicken preadipocytes, apparent lipid droplet formation and lipid accumulation were observed, accompanied by increasing expression of PPAR gamma (peroxisome proliferator-activated receptor-gamma) and AFABP (adipocyte fatty acid-binding protein), but decreasing level of GATA2 (GATA-binding protein 2). In contrast, for cells cultured in the basal medium with or without IDX supplementation, lipid droplet barely occurred. These results suggest that exogenous oleate alone can act as an inducer of preadipocyte differentiation into adipocytes.

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