A single-cell multi-omics atlas of rice

文献类型： 外文期刊

第一作者： Wang, Xiangyu

作者： Wang, Xiangyu;Li, Dongwei;Xie, Shang;Tong, Cheng;Liu, Chaofan;Hu, Guihua;Li, Haoqian;Li, Cong;Yang, Liwen;Liang, Zhe;Gu, Xiaofeng;Huang, Huanwei;Wang, Kailai;Li, Shang-Tong;Huang, Huanwei;Jiang, Sanjie;Kang, Jingmin;Ding, Yike;Wang, Faming;Lohmann, Jan U.

作者机构：

期刊名称：NATURE （ 影响因子：48.5； 五年影响因子：55.0 ）

ISSN： 0028-0836

年卷期： 2025 年 644 卷 8077 期

页码：

收录情况： SCI

摘要： Cell functions across eukaryotes are driven by specific gene expression programs, which are dependent on chromatin structure1, 2-3. Here we report a single-cell multi-omics atlas of rice, one of the world's major crops. By simultaneously profiling chromatin accessibility and RNA expression in 116,564 cells from eight organs, we identified cell-type-specific gene regulatory networks and described novel cell states, such as a 'transitional state' in floral meristems. On the basis of our network analyses, we uncovered the function of the cell-type-specific regulatory hubs RSR1, F3H and LTPL120 during rice development. Our analysis revealed correlations between cell type and agronomic traits, as well as conserved and divergent cell-type functions during evolution. In summary, this study not only offers a unique single-cell multi-omics resource for a major crop but also advances our understanding of cell-type functions and the underlying molecular programs in rice.

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