Solution Properties and in Vitro Anti-Tumor Activities of Polysaccharides from Longan Pulp

文献类型： 外文期刊

第一作者： Yi, Yang

作者： Yi, Yang;Huang, Fei;Zhang, Ming-Wei;Zhang, Rui-Fen;Deng, Yuan-Yuan;Wei, Zhen-Cheng;Yi, Yang;He, Jing-Ren

作者机构：

关键词： longan pulp;polysaccharide;solution property;conformation;anti-tumor activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2013 年 18 卷 9 期

页码：

收录情况： SCI

摘要： The solution properties of four fractions (LPI-IV) from crude longan pulp polysaccharides (LP3) were analyzed by size-exclusion chromatography combined with laser light scattering, viscometry, complex formation with Congo red, and atomic force microscopy. Their radii of gyration ((1/2)(z)) were 43.3, 62.6, 43.2 and 77.3 nm, exponents of (1/2)(z) = k M-w(v) were 0.04, 0.50, 0.52 and 0.02, and intrinsic viscosities ([eta]) were 9.945, 25.38, 308.2 and 452.1 mL/g, respectively. Moreover, the dependence of [eta] on M-w was established to be [eta] = 5.3 x 10(-2)M(w)(0.61) (mL/g). LPI had both a sphere-like conformation and a triple-helix structure, and LPII-IV existed as flexible chains. LP3, LPI, LPII and LPIII all exhibited direct inhibitory effects on A549, HeLa and HepG2 cells in a positive dose-dependent manner in the range of 50-400 mu g/mL. The activities of LPIII, especially the inhibition of HepG2 cell proliferation, were stronger than those of others, which may be partly related to its flexible conformation. The present results support the cancer therapeutic potential of longan polysaccharides.

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