Genome-wide association study of antibody response to Newcastle disease virus in chicken

文献类型： 外文期刊

第一作者： Luo, Chenglong

作者： Luo, Chenglong;Qu, Hao;Ma, Jie;Wang, Jie;Li, Chunyu;Yang, Chunfen;Shu, Dingming;Hu, Xiaoxiang;Li, Ning;Luo, Chenglong;Qu, Hao;Ma, Jie;Wang, Jie;Li, Chunyu;Yang, Chunfen;Hu, Xiaoxiang;Shu, Dingming

作者机构：

关键词： Chicken;Newcastle disease;Antibody response;Genome-wide association study

期刊名称：BMC GENETICS （ 影响因子：2.797； 五年影响因子：3.263 ）

ISSN： 1471-2156

年卷期： 2013 年 14 卷

页码：

收录情况： SCI

摘要： Background: Since the first outbreak in Indonesia in 1926, Newcastle disease has become one of the most common and contagious bird diseases throughout the world. To date, enhancing host antibody response by vaccination remains the most efficient strategy to control outbreaks of Newcastle disease. Antibody response plays an important role in host resistance to Newcastle disease, and selection for antibody response can effectively improve disease resistance in chickens. However, the molecular basis of the variation in antibody response to Newcastle disease virus (NDV) is not clear. The aim of this study was to detect genes modulating antibody response to NDV by a genome-wide association study (GWAS) in chickens. Results: To identify genes or chromosomal regions associated with antibody response to NDV after immunization, a GWAS was performed using 39,833 SNP markers in a chicken F-2 resource population derived from a cross between two broiler lines that differed in their resistance. Two SNP effects reached 5% Bonferroni genome-wide significance (P < 1.26x10(-6)). These two SNPs, rs15354805 and rs15355555, were both on chicken (Gallus gallus) chromosome 1 and spanned approximately 600 Kb, from 100.4 Mb to 101.0 Mb. Rs15354805 is in intron 7 of the chicken Roundabout, axon guidance receptor, homolog 2 (ROBO2) gene, and rs15355555 is located about 243 Kb upstream of ROBO2. Rs15354805 explained 5% of the phenotypic variation in antibody response to NDV, post immunization, in chickens. Rs15355555 had a similar effect as rs15354805 because of its linkage disequilibrium with rs15354805 (r(2) = 0.98). Conclusion: The region at about 100 Mb from the proximal end of chicken chromosome 1, including the ROBO1 and ROBO2 genes, has a strong effect on the antibody response to the NDV in chickens. This study paves the way for further research on the host immune response to NDV.

分类号：

  • 相关文献

[1]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[2]Chimeric rabies glycoprotein with a transmembrane domain and cytoplasmic tail from Newcastle disease virus fusion protein incorporates into the Newcastle disease virion at reduced levels. Yu, Gui Mei,Zu, Shu Long,Zhou, Wei Wei,Wang, Xi Jun,Shuai, Lei,Wang, Xue Lian,Ge, Jin Ying,Bu, Zhi Gao. 2017

[3]Association of SNPs in exon 2 of the MHC B-F gene with immune traits in two distinct chicken populations: Chinese Beijing-You and White Leghorn. Liu, L. B.,Wu, C. M.,Wen, J.,Chen, J. L.,Zheng, M. Q.,Zhao, G. P..

[4]Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Wang, Gang,Song, Tengfei,Liu, Yonggang,Shi, Wenda,Wang, Shujie,Rong, Fulong,Dong, Jianguo,Liu, He,Cai, Xuehui,Wang, Gang,Song, Tengfei,Yu, Ying,Zhou, En-Min,Zhou, En-Min.

[5]Babesia gibsoni: An apical membrane antigen-1 homologue and its antibody response in the infected dogs. Zhou, Jinlin,Yang, Jun,Zhang, Guohong,Nishikawa, Yoshifumi,Fujisaki, Kozo,Xuan, Xuenan. 2006

[6]A 38-kDa protein from Babesia gibsoni and its antibody response in an experimentally infected dog. Zhou, Jinlin,Zhang, Guohong,Nishikawa, Yoshifumi,Fujisaki, Kozo,Xuan, Xuenan. 2006

[7]Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge. Wen, Zhiyuan,Ye, Ling,Gao, Yulong,Pan, Lei,Dong, Ke,Compans, Richard W.,Yang, Chinglai,Wen, Zhiyuan,Ye, Ling,Gao, Yulong,Pan, Lei,Dong, Ke,Compans, Richard W.,Yang, Chinglai,Wen, Zhiyuan,Gao, Yulong,Bu, Zhigao,Pan, Lei,Dong, Ke. 2009

[8]Chinese border disease virus strain JSLS12-01 infects piglets and down-regulates the antibody responses of classical swine fever virus C strain vaccination. Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Mao, Li,Li, Wenliang,Liu, Xia,Hao, Fei,Yang, Leilei,Deng, Jiawu,Zhang, Wenwen,Jiang, Jieyuan,Liu, Xia,Deng, Jiawu,Wei, Jianzhong.

[9]Enhancement of immune responses to Newcastle disease vaccine by a supplement of extract of Momordica cochinchinensis (Lour.) Spreng. seeds. Xiao, C.,Hu, S.,Xiao, C.,Bao, G.. 2009

[10]Biological evaluation of N-2-hydroxypropyl trimethyl ammonium chloride chitosan as a carrier for the delivery of live Newcastle disease vaccine. Zhao, Kai,Wang, Xiaohua,Zhao, Kai,Sun, Yanwei,Chen, Gang,Rong, Guangyu,Kang, Hong,Wang, Xiaohua,Sun, Yanwei,Jin, Zheng.

[11]Expression analyses and antiviral properties of the Beijing-You and White Leghorn myxovirus resistance gene with different amino acids at position 631. Du, L. X.,Zhao, G. P.,Zhang, C. S..

[12]Enhancing Mucosal Immune Response of Newcastle Disease Virus DNA Vaccine Using N-2-Hydroxypropyl Trimethylammonium Chloride Chitosan and N,O-Carboxymethyl Chitosan Nanoparticles as Delivery Carrier. Zhao, Kai,Zhang, Yang,Wei, Lin,Yu, Shuang,Wang, Xiaohua,Han, Jinyu,Jin, Zheng,Wang, Yunfeng. 2018

[13]Synthesis, characterization, and immune efficacy of layered double hydroxide@SiO2 nanoparticles with shell-core structure as a delivery carrier for Newcastle disease virus DNA vaccine. Zhao, Kai,Rong, Guangyu,Guo, Chen,Luo, Xiaomei,Kang, Hong,Sun, Yanwei,Wang, Xiaohua,Wang, Xin,Sun, Qingshen,Rong, Guangyu,Sun, Yanwei,Cui, Shangjin,Dai, Chunxiao,Jin, Zheng. 2015

[14]Quaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administration. Zhao, Kai,Li, Shanshan,Li, Wei,Yu, Lu,Duan, Xutong,Wang, Xiaohua,Zhao, Kai,Li, Shanshan,Yu, Lu,Duan, Xutong,Han, Jinyu,Jin, Zheng. 2017

[15]Rapid discrimination of H5 and H9 subtypes of avian influenza viruses and Newcastle disease virus by multiplex RT-PCR. Chen, Hao-tai,Zhang, Jie,Sun, De-hui,Zhang, Ji-le,Cai, Xue-peng,Liu, Xiang-tao,Ding, Yao-zhong,Ma, Li-na,Yang, Sheng-hai,Jin, Lei,Liu, Yongsheng. 2008

[16]Novel in-ovo chimeric recombinant Newcastle disease vaccine protects against both Newcastle disease and infectious bursal disease. Ge, Jinying,Wang, Xijun,Tian, Meijie,Wen, Zhiyuan,Feng, Qiulin,Qi, Xiaole,Gao, Honglei,Wang, Xiaomei,Bu, Zhigao. 2014

[17]Detection of Newcastle disease virus using nucleic acid sequence-based amplification. Cui, Shang-Jin,Fung, Yin-Wan Wendy,Lau, Lok Ting,Liu, Wen-Bin,Wang, Yun-Feng,Tong, Guang-Zhi,Chen, Jianguo,Yu, Albert Cheung Hoi. 2007

[18]O-2 '-Hydroxypropyltrimethyl ammonium chloride chitosan nanoparticles for the delivery of live Newcastle disease vaccine. Dai, Chunxiao,Kang, Hong,Rong, Guangyu,Wang, Xiaohua,Wang, Xin,Zhao, Kai,Dai, Chunxiao,Cheng, Guogang,Jin, Zheng,Yang, Wanqiu,Sun, Jinyan,Liu, Chunlong.

[19]Genome-Wide Association and Transcriptome Analyses Reveal Candidate Genes Underlying Yield-determining Traits in Brassica napus. Lu, Kun,Peng, Liu,Zhang, Chao,Lu, Junhua,Yang, Bo,Xiao, Zhongchun,Liang, Ying,Xu, Xingfu,Qu, Cunmin,Zhang, Kai,Liu, Liezhao,Li, Jiana,Peng, Liu,Zhang, Chao,Zhu, Qinlong,Fu, Minglian,Yuan, Xiaoyan. 2017

[20]Genome-wide association study of salt tolerance at the seed germination stage in rice. Wu, Zhichao,Zhang, Xiaojing,Wang, Mingming,Zhang, Congshun,Zhang, Fan,Zhou, Yongli,Li, Zhikang,Shi, Yingyao,Gao, Lingling,Zhou, Yongli,Li, Zhikang. 2017

作者其他论文 更多>>

微信小程序