文献类型： 外文期刊

第一作者： Yong-Xue, S.

作者： Yong-Xue, S.;Yongjin, L.;Dongping, Z.;Zhichang, L.;Haiyan, Z.;Gang, W.

作者机构：

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2012 年 35 卷 1 期

页码：

收录情况： SCI

摘要： Pharmacokinetics of Rhizoma Curcumae oil-pure drug (RCO-PD) and its beta-cyclodextrin inclusion complex (RCO-beta CD) were studied in a randomized twoway crossover design following a single oral administration of the two formulations. Germacrone concentrations in plasma were determined by high-performance liquid chromatography with UV detector. The concentrations vs. time data were analyzed by a noncompartmental pharmacokinetic method. The result showed that germacrone in both groups was rapidly absorbed followed by a slow elimination. The main parameters in RCO-PD group were as follows: t(1/2 lambda z) 6.63 +/- 1.08 h, C(max) 2.50 +/- 0.34 mu g /mL, MRT 7.19 +/- 0.93 h, and AUC(0-infinity) 13.92 +/- 2.75 mg/L.h, while in RCO-bCD group, t(1/2 lambda z) 6.77 +/- 0.67 h, C(max) 2.98 +/- 0.24 mu g /mL, MRT 8.87 +/- 0.76 h, and AUC(0-infinity) 21.60 +/- 1.95 mg/L h, respectively. The above results indicated that C(max), T(max), AUC0-t, AUC(0-infinity), and MRT in RCO-beta CD group were significantly different from RCO-PD group, and the relative bioavailability of RCO-beta CD group is significantly higher while compared to RCO-PD group (F = 156%, with its 90% confidence interval of 145-169%).

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