Integration of metabolomics and transcriptomics indicates changes in MRSA exposed to terpinen-4-ol
文献类型： 外文期刊
第一作者： Cheng, Feng
作者： Cheng, Feng;Mo, Yanan;Chen, Keyuan;Shang, Xiaofei;Yang, Zhen;Hao, Baocheng;Shang, Ruofeng;Liang, Jianping;Liu, Yu
作者机构：
关键词： Terpinen-4-ol; MRSA; Biofilm; Metabolomics; Transcriptomics
期刊名称：BMC MICROBIOLOGY （ 影响因子：3.605； 五年影响因子：4.283 ）
ISSN： 1471-2180
年卷期： 2021 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Background: This study investigated the effects of terpinen-4-ol on methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, and the possible mechanisms governing this effect. Results: We observed that terpinen-4-ol has good antibacterial activity and inhibits the formation of MRSA biofilm. The MIC and MBC values for terpinen-4-ol against S. aureus were 0.08%similar to 0.32%. And terpinen-4-ol at 0.32% could kill all bacteria and clear all biofilms. Untargeted metabolomic and transcriptomic analyses showed that terpinen-4-ol strongly inhibited DNA and RNA biosynthesis in MRSA at 2 h after treatment by affecting genes and metabolites related to purine and pyrimidine metabolic pathways. Some differential genes which play important roles in DNA synthesis and the production of eDNA from biofilm exposed to terpinen-4-ol was also significantly decreased compared with that of the control. Conclusions: Terpinen-4-ol has good antibacterial activity and significantly inhibits the formation of MRSA biofilm by inhibiting purine and pyrimidine metabolism.
分类号：
- 相关文献
作者其他论文 更多>>
-
Microbial Communities in Food Waste in Terms of Methanogenic and Residue Gob Remediation Potentials
作者：Wang, Lizhi;Wang, Lizhi;Liu, Yu;Chen, Congcong;Yang, Yuyan;Cheng, Fei;Xu, Zhilei
关键词：food waste; traditional Chinese festivals; bacterial diversity; archaeal diversity; methanogens
-
Fertilizer application parameters for drip-irrigated peanut based on the fertilizer effect function established from a "3414" field trial
作者：Gao, Zhijian;Liu, Yu;Wang, Guodong;Yang, Guojiang;Liu, Yantao;Wang, Liang;Gao, Zhijian;Liu, Yu;Wang, Guodong;Yang, Guojiang;Gao, Zhijian;Liu, Yu;Wang, Guodong;Yang, Guojiang;Bai, Xinlu;Zhi, Jinhu;Tang, Xiaoyun
关键词：peanut yield; mulched drip irrigation; "3414" field trial; fertilizer effect model; recommended fertilization
-
Estimating Fraction of Absorbed Photosynthetically Active Radiation of Winter Wheat Based on Simulated Sentinel-2 Data under Different Varieties and Water Stress
作者：Sun, Zheng;Sun, Liang;Liu, Yu;Li, Yangwei;Chen, Ruiqing;Wuyun, Deji;Crusiol, Luis Guilherme Teixeira
关键词：fraction of absorbed photosynthetically active radiation; MNDVI; winter wheat; vegetation index; Sentinel-2
-
Diversity of Trichoderma species associated with green mold contaminating substrates of Lentinula edodes and their interaction
作者：Cao, Zi-Jian;Zhao, Juan;Liu, Yu;Wang, Shou-Xian;Qin, Wen-Tao;Cao, Zi-Jian;Zheng, Su-Yue
关键词：Hypocreaceae; Trichoderma; green mold; Lentinula edodes; phylogeny; morphology; taxonomy
-
Large-scale gene expression alterations introduced by structural variation drive morphotype diversification in Brassica oleracea
作者：Li, Xing;Wang, Yong;Cai, Chengcheng;Ji, Jialei;Han, Fengqing;Zhang, Lei;Chen, Shumin;Zhang, Lingkui;Yang, Yinqing;Tang, Qi;Wang, Xuelin;Yang, Limei;Zhuang, Mu;Zhang, Kang;Lv, Honghao;Zhang, Yangyong;Cheng, Feng;Cai, Chengcheng;Bucher, Johan;Bonnema, Guusje
关键词：
-
Subsurface organic amendment of a saline soil increases ecosystem multifunctionality and sunflower yield
作者：Song, Jiashen;Zhang, Hongyuan;Chang, Fangdi;Yu, Ru;Wang, Jing;Li, Yuyi;Chen, Aiping;Xu, Yang;Liu, Yu;Zhou, Jie;Li, Yuyi
关键词：Soil quality; Enzyme activity; Soil ecosystem multifunctionality; Crop yield; Humic acid and manure; Salinization
-
Reduction of nutrient fluxes across the sediment-water interface and nutrient accumulation in lotus-fish co-culture aquaculture ponds
作者：Peng, Liang;Dai, Lili;Li, Gu;Tao, Ling;Zhang, Hui;Yang, Zhen;Sun, Meng;Zhu, Jianqiang;Yang, Zhen
关键词：Aquaculture ponds; Lotus planting; Sediment-water interface; Nitrogen and phosphorus flux
