Synthesis and Characterization of Ethylenediamine Tetraacetic Acid Tetrasodium Salt Loaded in Microcapsules with Slow Release Properties

文献类型： 外文期刊

第一作者： Xie Zhiyi

作者： Xie Zhiyi;Chen Nengchang;Liu Chengshuai;Zhou Jianmin;Xu Shengguang;Zheng Yuji;Li Fangbai;Xu Yanling;Xie Zhiyi;Xie Zhiyi

作者机构：

关键词： Na-4-EDTA microcapsules;interfacial polymerization;controlled release

期刊名称：CHINESE JOURNAL OF CHEMICAL ENGINEERING （ 影响因子：3.171； 五年影响因子：2.853 ）

ISSN： 1004-9541

年卷期： 2010 年 18 卷 1 期

页码：

收录情况： SCI

摘要： The microcapsules with cores of ethylenediamine tetraacetic acid tetrasodium salt (Na-4-EDTA) and walls of polyurea were synthesized via an interfacial polycondensation reaction with 2,4-tolylene diisocyanate as an oil-soluble monomer and diethyl triamine as a water-soluble monomer Various manufacturing parameters, including the amount of emulsifier, agitation speed, stirring time and ratios of the wall materials to core materials, were altered to optimize process variables during the synthesis of microcapsules, and the effects of these parameters on the characteristics of the microcapsules were examined. The structure, morphology, mean particle size and size distribution were characterized by optical microscope and scanning electron microscopy (SEM), showing that the mean diameter of optimal microspheres was approximately 6 pm, and microcapsules were spherical In vitro release of Na4-EDTA from these microcapsules was performed in distilled water. Under the optimal preparation conditions, the Na-4-EDTA release profiles were biphasic with a burst release followed by a gradual release phase After an initial burst, a continuous Na-4-EDTA release was up to 5-7 days The optimal synthesis conditions for the microcapsules with stable, good morphology and good controlled-release properties were as follows emulsifier Span-80 10% (by mass), agitation speed 900 r min(-1), stirring time 30 min, and the ratio of the wall materials to core materials 0.15

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