Influenza A virus induces p53 accumulation in a biphasic pattern

文献类型： 外文期刊

第一作者： Shen, Yang

作者： Shen, Yang;Wang, Xiaodu;Guo, Lin;Qiu, Yafeng;Li, Xiangdong;Yu, Hai;Tong, Guangzhi;Ma, Zhiyong;Xiang, Hua

作者机构：

关键词： Influenza A virus;p53;p53 pathway;Innate antiviral response

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2009 年 382 卷 2 期

页码：

收录情况： SCI

摘要： Tumor suppressor p53, the major cellular defense against tumor development, has recently been implicated in host antiviral defense. Previous studies have shown that p53 was induced at the apoptotic stage of influenza virus-infected cells. However. we found that p53 was induced not only at the apoptotic stage but also at the beginning phase of infection, showing a biphasic pattern with a first transient elevation apparent at the beginning phase of infection and a second elevation observable at the middle-late phase of infection. This up-regulation of p53 was independent of increased p53 transcription, but dependent on Virus adsorption and replication. The increased p53 was active and able to transactivate its downstream target genes, Such as interferon regulatory factor 9 (IRF9) and Bax. To our knowledge, this is the first report to describe a biphasic pattern of p53 accumulation in influenza virus-infected cells. (C) 2009 Elsevier Inc. All rights reserved.

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