Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo
文献类型: 外文期刊
第一作者: Zhang, Linghua
作者: Zhang, Linghua;Zhang, Meirong;Li, Jiaoqing;Cao, Ting;Tian, Xingshan;Zhou, Fengzhen
作者机构:
关键词: The SPF chickens;Newcastle disease vaccine;CpG ODN;Immune responses
期刊名称:RESEARCH IN VETERINARY SCIENCE ( 影响因子:2.534; 五年影响因子:2.382 )
ISSN: 0034-5288
年卷期: 2008 年 85 卷 3 期
页码:
收录情况: SCI
摘要: Immunostimulatory CpG oligodeoxynuclcotides (ODN) have been tested as immunoadjuvants for various vaccines in mice and human. Findings from previous reports suggest that CpG ODN can be used to enhance magnitude and balance of an immune response while reducing undesirable side effects of commercial vaccine, when delivered by parenteral route. Recently, it has been showed that CpG ODN is a promising mucosal adjuvant in mice, but data on mucosal immune responses induced by CpG ODN in other animals, especially in chickens, are scarce. Herein, we evaluated intranasal (IN) delivery of CpG ODN with newcastle disease (ND) vaccine (NDV) to determine its potential as a mucosal adjuvant to a commercial vaccine. CpG ODN augmented systemic (IgG in serum, T cell proliferation) and mucosal (IgA in intestinal washings and feces) immune responses against antigen. CpG ODN stimulated effectively both systemic and mucosal immune responses when delivered intranasally. Results from this study indicate that stimulatory CpG ODN is a potential effective mucosal adjuvant for the NDV in SPF chickens and may be applicable to husbandry animals. (C) 2008 Elsevier Ltd. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Allelopathic effects of Borreria latifolia on weed germination and identification of allelochemicals
作者:Zhang, Tai-Jie;Guo, Wenlei;Tian, Xingshan;Lv, Yin-Zhi;Feng, Kai-Fan;Zhang, Chun
关键词:allelopathy; Borreria latifolia; coumarin; germination; weed
-
20-Hydroxyecdysone Regulates the Expression of 30 Genes Specifically Expressed in Larval Digestive Tube of the Silkworm, Bombyx mori
作者:Li, Jiahao;Xia, Mulin;Huang, Songyao;Zhang, Guangxie;Tang, Yuncheng;Xu, Pingzhen;Zhang, Meirong;Li, Jiahao;Xia, Mulin;Huang, Songyao;Zhang, Guangxie;Xu, Pingzhen;Zhang, Meirong;Tang, Yuncheng
关键词:
Bombyx mori ; digestive tube; 20-hydroxyecdysone; larval-to-larval molting; wandering -
Impact of dietary Alpinia Katsumadai extracts on production performance, meat quality, and gene expression in AMPK signaling regulatory pathway of Wuzhishan pigs
作者:Wu, Hongzhi;Yu, Xilong;Zhang, Xiaoyu;Peng, Weiqi;Ji, Fengjie;Li, Hanfeng;Cao, Ting;Lv, Renlong;Ipemba, Euphreme;Bakala, Ghislain Boungou;Leveut, Lessebe Gambou Dieu
关键词:Alpinia Katsumadai extracts; meat quality; amino acids; long-chain fatty acids; AMPK signaling pathway
-
Comparative transcriptome analysis of midgut of Bombyx mori under a sucrose-supplemented diet
作者:Hu, Zhenbin;Zhan, Lijie;Chen, Xinyi;Li, Jia;Zhang, Meirong;Xu, Pingzhen;Hu, Zhenbin;Zhan, Lijie;Chen, Xinyi;Li, Jia;Zhang, Meirong;Xu, Pingzhen
关键词:Silkworm; Sucrose; Midgut; Metabolism; Transcriptome
-
Effects of dietary supplementation with bile acids on growth performance, antioxidant capacity, lipid metabolism, and cecal microbiota of Danzhou chickens
作者:Yu, Xilong;Cao, Ting;Peng, Weiqi;Ji, Fengjie;Li, Hanfeng;Wu, Hongzhi;Ipemba, Euphreme;Bakala, Ghislain Boungou;Leveut, Lessebe Gambou Dieu;Yu, Xilong;Xu, Liangmei
关键词:Bile acid; Danzhou chicken; Production performance; Lipid metabolism; Antioxidant activity
-
Haplotype-resolved chromosomal-level genome assembly reveals regulatory variations in mulberry fruit anthocyanin content
作者:Xia, Zhongqiang;Fan, Wei;Liu, Duanyang;Chen, Yuane;Lv, Jing;Xu, Mengxia;Zhang, Meirong;Ren, Zuzhao;Chen, Xuefei;Wang, Xiujuan;Li, Liang;Zhao, Aichun;Zhu, Panpan;Zhu, Panpan;Liu, Changying;Song, Zhiguang;Huang, Chuanshu;Wang, Xiling;Wang, Shuchang
关键词:
-
Impact of dietary protein and energy levels on fatty acid profile, gut microbiome and cecal metabolome in native growing chickens
作者:Zhou, Luli;Wang, Dingfa;Abouelezz, Khaled;Shi, Liguang;Cao, Ting;Hou, Guanyu;Abouelezz, Khaled
关键词:metabolizable energy; crude protein; fatty acid; gut metabolism; native growing chicken