A protective mechanism of heat inactivation to enhance Levilactobacillus brevis PDD-2 against alcohol-induced chronic liver disease based on proteomic analysis

文献类型： 外文期刊

第一作者： Liu, Mingzhen

作者： Liu, Mingzhen;Zeng, Xiaoqun;Zhang, Tao;Fan, Xiankang;Xu, Jue;Wu, Zhen;Pan, Daodong;Liu, Mingzhen;Zeng, Xiaoqun;Zhang, Tao;Fan, Xiankang;Xu, Jue;Wu, Zhen;Pan, Daodong;Jiang, Xiaoxiao;Guo, Yuxing;Jiang, Xiaoxiao

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：5.1； 五年影响因子：5.6 ）

ISSN： 2042-6496

年卷期： 2024 年 15 卷 16 期

页码：

收录情况： SCI

摘要： A proteomics-based analysis of the effect of heat inactivation on the alleviation of alcoholic liver disease (ALD) using Levilactobacillus brevis PDD-2 is presented, aimed at exploring the potential and mechanisms of postbiotic elements prepared through heat inactivation in the treatment of ALD. It was found that L. brevis PDD-2 and its postbiotic (heat-inactivated L. brevis PDD-2) alleviate chronic ALD via the gut-liver axis. In particular, heat-inactivated L. brevis PDD-2 significantly increased the relative abundance of Erysipelotrichaceae and better facilitated the oxidative stress balance in the liver. The tandem mass tag (TMT)-based quantitative proteomics technique analyses revealed that heat-inactivated L. brevis PDD-2 was associated with up-regulated expression levels of proteins related to the redox system, cellular metabolism, amino acid and oligopeptide transport, and surface proteins with immunomodulatory capacity. These findings provide a theoretical basis for developing novel therapeutic strategies and lay a solid foundation for further revealing its exhaustive mechanisms.

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