A Molecular Switch-Integrated Nanoplatform Enables Photo-Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy

文献类型： 外文期刊

第一作者： Yan, Yunxiang

作者： Yan, Yunxiang;Li, Juanjuan;Wu, Haoheng;Ma, Xiang;Tang, Yanqiong;Tong, Yuan;Liu, Zhu;Yan, Yunxiang;Li, Juanjuan;Wu, Haoheng;Li, Hong;Ma, Xiang;Tang, Yanqiong;Tong, Yuan;Liu, Zhu;Liu, Yong;Li, Ye;Yi, Kexian;Liang, Quanfeng

作者机构：

关键词： antibacterial activity; hollow mesoporous silica nanoparticles; MRSA; wound healing

期刊名称：ADVANCED HEALTHCARE MATERIALS （ 影响因子：10.0； 五年影响因子：10.6 ）

ISSN： 2192-2640

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Drug delivery systems (DDSs) capable of sequential multistage drug release are urgently needed for antibacterial applications. Herein, a molecular switch-integrated, photo-responsive nanoplatform is reported based on hollow mesoporous silica nanospheres (HMSN) loaded with silver nanoparticles (Ag NPs), vancomycin (Van), and hemin (HAVH) for bacteria elimination and abscess therapy. Upon near-infrared (NIR) light irradiation, the molecular switch, hemin, can effuse from the mesopores of HMSN, triggering the release of pre-loaded Ag+ and Van, which enables photothermal-modulated drug release and synergistic photothermal-chemo therapy (PTT-CHT). The HAVH_NIR irreversibly disrupts the bacterial cell membrane, facilitating the penetration of Ag+ and Van. It is found that these compounds restrain the transcription and translation of ribosomes and lead to rapid bacterial death. Furthermore, hemin can effectively inhibit excessive inflammatory responses associated with the treatment, promoting accelerated wound healing in a murine abscess model. This work presents a new strategy for antibacterial drug delivery with high controllability and extendibility, which may benefit the development of smart multifunctional nanomedicine for diseases not limited to bacterial infections.

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