Structural and Evolutionary Adaptation of NOD-Like Receptors in Birds

文献类型： 外文期刊

第一作者： Ma, Xueting

作者： Ma, Xueting;Liu, Baohong;Gong, Zhenxing;Yu, Xinmao;Cai, Jianping;Ma, Xueting;Liu, Baohong;Gong, Zhenxing;Yu, Xinmao;Cai, Jianping

作者机构：

期刊名称：BIOMED RESEARCH INTERNATIONAL （ 影响因子：3.411； 五年影响因子：3.62 ）

ISSN： 2314-6133

年卷期： 2021 年 2021 卷

页码：

收录情况： SCI

摘要： NOD-like receptors (NLRs) are intracellular sensors of the innate immune system that recognize intracellular pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Little information exists regarding the incidence of positive selection in the evolution of NLRs of birds or the structural differences between bird and mammal NLRs. Evidence of positive selection was identified in four avian NLRs (NOD1, NLRC3, NLRC5, and NLRP3) using the maximum likelihood approach. These NLRs are under different selection pressures which is indicative of different evolution patterns. Analysis of these NLRs showed a lower percentage of codons under positive selection in the LRR domain than seen in the studies of Toll-like receptors (TLRs), suggesting that the LRR domain evolves differently between NLRs and TLRs. Modeling of human, chicken, mammalian, and avian ancestral NLRs revealed the existence of variable evolution patterns in protein structure that may be adaptively driven.

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