Comparative study on Pharmacokinetic Profiles of Chicken IgY to Horse IgG in Rabbits

文献类型： 外文期刊

第一作者： Zhou, Zhaoxiang

作者： Zhou, Zhaoxiang;Zhang, Xiaoying;Gao, Song;Ren, Hao;Xie, Wenyan;Zhang, Xiaoying;Wang, Jian;Thirumalai, Diraviyam

作者机构：

关键词： tetanus;IgY;IgG;pharmacokinetics;intravenous administrations;intramuscular administrations

期刊名称：JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY （ 影响因子：0.477； 五年影响因子：0.517 ）

ISSN： 1792-2720

年卷期： 2017 年 68 卷 3 期

页码：

收录情况： SCI

摘要： Chicken IgY antibody has been extensively reported for various applications as an alternative to mammalian IgG. To evaluated the pharmacokinetics profile of chicken IgY in comparison with horse IgG. Chicken IgY antibody was prepared by immunizing the white leghorn chicken with tetanus toxoid (TT) and then extracted anti-TT-IgY from immune egg yolks by PEG-6000 extraction. The titer of anti-TT-IgY was determined by ELISA in order to select the hyper immune eggs for further extraction. Rabbits were injected with 300 mu g/kg of Chicken IgY and horse IgG by intravenous (i.v.) and intramuscular (i.m.) administrations. Then, the concentrations of IgY and IgG in rabbit serum were determined using indirect ELISA. Pharmacokinetic parameters were estimated using non-compartmental analysis. IgY can reach higher concentration (C-max = 4.54 mg/L after i.m. injection) within shorter time (T-max = 0.12 h after i.m. injection) than IgG (C-max = 3.99 ng/mL after i.m. injection; T-max = 0.11 h after i.m. injection), while the IgY lifespan (T-1/2 = 26.98 h and 31.98 h after i.v. and i.m. administration, respectively) in the body was comparable with IgG (T-1/2 = 27.94 h and 29.58 h after i.v. and i.m. administration, respectively). IgY might be a promising choice as an alternative to mammalian sourced antibodies.

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