miR-34a targets the inhibin beta B gene, promoting granulosa cell apoptosis in the porcine ovary

文献类型： 外文期刊

第一作者： Tu, F.

作者： Tu, F.;Pan, Z. X.;Yao, Y.;Liu, H. L.;Xie, Z.;Li, Q. F.;Liu, S. R.

作者机构：

关键词： miR-34a;INHBB;Apoptosis;Granulosa cells

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2014 年 13 卷 2 期

页码：

收录情况： SCI

摘要： During ovarian follicular growth and development, only a few follicles actually ovulate. Recently, it was found that follicular atresia is triggered by granulosa cell apoptosis, but the molecular mechanism of follicular atresia was not understood. Using flow cytometry, we found that miR-34a promotes granulosa cell apoptosis in pig ovarian follicles. In addition, inhibin beta B was found to be a miR-34a target gene, based on luciferase reporter assays, quantitative RTPCR and Western blotting. Taken together, our data indicate that miR-34a plays an important role in granulosa cell apoptosis by targeting the INHBB gene in the porcine ovary.

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