Protective Effects of Blueberry Anthocyanins against H2O2-Induced Oxidative Injuries in Human Retinal Pigment Epithelial Cells
文献类型: 外文期刊
第一作者: Huang, Wu-Yang
作者: Huang, Wu-Yang;Wu, Han;Li, Da-Jing;Song, Jiang-Feng;Xiao, Ya-Dong;Liu, Chun-Quan;Zhou, Jian-Zhong;Huang, Wu-Yang;Sui, Zhong-Quan
作者机构:
关键词: age-related macular degeneration;antioxidant;blueberry anthocyanins;oxidative stress;retinal pigment epithelial cells
期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )
ISSN: 0021-8561
年卷期: 2018 年 66 卷 7 期
页码:
收录情况: SCI
摘要: Blueberry anthocyanins are considered protective of eye health because of their recognized antioxidant properties. In this study, blueberry anthocyanin extract (BAE), malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), and malvidin-3-galactoside (Mv-3-gal) all reduced H2O2-induced oxidative stress by decreasing the levels of reactive oxygen species and malondialdehyde and increasing the levels of superoxide dismutase, catalase, and glutathione peroxidase in human retinal pigment epithelial cells. BAE and the anthocyanin standards enhanced cell viability from 63.69 +/- 3.36 to 86.57 +/- 6.92% (BAE), 115.72 +/- 23.41% (Mv), 98.15 +/- 9.39% (Mv-3-glc), and 127.97 +/- 20.09% (Mv-3-gal) and significantly inhibited cell apoptosis (P < 0.01 for all). Mitogen-activated-protein-kinase pathways, including ERK1/2 and p38, were involved in the bioactivities. In addition, the anthocyanins decreased vascular-endothelial-cell-growth-factor levels and activated Akt-signal pathways. These combined results supported the hypothesis that blueberry anthocyanins could inhibit the induction and progression of age-related macular degeneration (AMD) through antioxidant mechanisms.
分类号:
- 相关文献
作者其他论文 更多>>
-
Involvement of Sep38β in the Insecticidal Activity of Bacillus thuringiensis against Beet Armyworm, Spodoptera exigua (Lepidoptera)
作者:Ji, Yujie;Gao, Bo;Wang, Yao;Zhang, Lu;Wu, Han;Xie, Yifan;Shi, Qiuyu;Guo, Wei;Zhao, Dan
关键词:bioinformatics analysis; expression pattern; ROS level; bacterial load; insecticidal activity; Spodoptera exigua
-
Somatic embryogenesis from mature sorghum seeds: An underutilized genome editing recipient system
作者:Wu, Han;Zhang, Kuangye;Li, Jia;Wang, Jiaxu;Wang, Yanqiu;Cong, Ling;Duan, Youhou;Ke, Fulai;Zhang, Fei;Liu, Zhiqiang;Lu, Feng;Zhang, Zhipeng;Zou, Jianqiu;Zhu, Kai;Yu, Junchi
关键词:Somatic embryogenesis; Regeneration; Sorghum; Seeds; Genome editing; Recipient
-
The effects of polysaccharides, organic acids and colloids on the stability of anthocyanin in purple corn
作者:Pang, Wen-qian;Zhao, Han;Li, Da-jing;Li, Yue;Liu, Chun-ju;Yu, Rui;Pang, Wen-qian;Zhao, Han;Li, Yue;Yu, Rui
关键词:Anthocyanin; colloid; organic acid; polysaccharide; purple corn
-
Integrated Metagenomics and 15N Isotope Tracing Reveal the Mechanisms Through which the Nitrogen-Planting Density Interaction Impacts Rice Root Nitrogen Uptake Efficiency
作者:Sun, Changhui;Lu, Yanyao;Wang, Runnan;Wu, Han;Zhang, Jiao;Zhu, Jinyan;Xiong, Qiangqiang;Sun, Changhui;Lu, Yanyao;Wang, Runnan;Wu, Han;Zhang, Jiao;Zhu, Jinyan;Xiong, Qiangqiang;Tang, Guoping;Cai, Shuo;Xiong, Qiangqiang
关键词:Rice; Density; Nitrogen Uptake Efficiency; Enzyme Activity; Isotope Tracing; Metagenomics
-
A rotated rice spike detection model and a crop yield estimation application based on UAV images
作者:Liang, Yunting;Wu, Han;Zhao, Yinwei;Liu, Zhijie;Liu, Dong;Liu, Zongru;Fan, Gangao;Shen, Zhuo;Lv, Jia;Li, Jiyu;Li, Huifen;Pan, Zhaoyang
关键词:Rotated feature; Rice spike detection; YOLOv5; Attention mechanism; Unmanned aerial vehicle (UAV)
-
Influences of wind vortex intensity of rotor UAV on rice morphology and yield
作者:Wei, Xu;Zhang, Zhixun;Wu, Han;Lv, Jia;Li, Jiyu;Zhou, Meizhen;Wei, Xu;Zhang, Zhixun;Wu, Han;Lv, Jia;Li, Jiyu;Li, Huifen;Wu, Longmei
关键词:Rice; Agricultural aviation; Rotor UAV; Wind vortex intensity; Yield
-
Effects of the pyrE deletion mutant from Bacillus thuringiensis on gut microbiota and immune response of Spodoptera exigua
作者:Zhao, Dan;Wu, Han;Li, Yazi;Wang, Qian;Guo, Xiaochang;Guo, Wei;Wu, Han;Ji, Yujie;Guo, Wei
关键词:Bt GS57opyrE; uracil; gut microbiota; immune gene; Spodoptera exigua