Malvidin and its Glycosides from Vaccinium ashei Improve Endothelial Function by Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory Effects

文献类型： 外文期刊

第一作者： Huang, Wu-Yang

作者： Huang, Wu-Yang;Wang, Xing-Na;Wang, Jing;Sui, Zhong-Quan

作者机构：

关键词： Blueberry;Malvidin and glycosides;Anti-inflammation;ACE inhibitor;Endothelial cells

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN： 1934-578X

年卷期： 2018 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-alpha, and inhibit monocyte chemotactic protein 1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of I kappa B alpha and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF-kappa B pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.

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