A Bacterial Type III Effector Targets the Master Regulator of Salicylic Acid Signaling, NPR1, to Subvert Plant Immunity

文献类型： 外文期刊

第一作者： Chen, Huan

作者： Chen, Huan;Chen, Jian;Chang, Ming;Zhao, Yi;Liu, Fengquan;Chen, Huan;Chen, Jian;Li, Min;Chang, Ming;Xu, Kaimei;Shang, Zhenhua;Zhao, Yi;Palmer, Ian;Zhang, Yuqiang;McGill, Jon;Fu, Zheng Qing;Zhang, Yuqiang;Alfano, James R.;Alfano, James R.;Nishimura, Marc T.

作者机构：

期刊名称：CELL HOST & MICROBE （ 影响因子：21.023； 五年影响因子：22.103 ）

ISSN： 1931-3128

年卷期： 2017 年 22 卷 6 期

页码：

收录情况： SCI

摘要： Most plant bacterial pathogens rely on type III effectors to cause diseases. Although it is well known that the plant hormone salicylic acid (SA) plays an essential role in defense, whether the master regulator of SA signaling, NPR1, is targeted by any plant pathogen effectors is unknown. SA facilitates the reduction of cytosolic NPR1 oligomers into monomers, which enter the nucleus and function as transcriptional coactivators of plant defense genes. We show that SA promotes the interaction between the Pseudomonas syringae type III effector AvrPtoB and NPR1. In the presence of SA, AvrPtoB mediates the degradation of NPR1 via the host 26S proteasome in a manner dependent on AvrPtoB's E3 ligase activity. Intriguingly, we found that NPR1 plays an important role in MAMP-triggered immunity (MTI), inducing the expression of MTI marker genes. Thus, this work uncovers a strategy in which AvrPtoB targets NPR1 and represses NPR1-dependent SA signaling, thereby subverting plant innate immunity.

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