The immune mechanism of Mycoplasma hyopneumoniae 168 vaccine strain through dendritic cells

文献类型： 外文期刊

第一作者： Shen, Yumeng

作者： Shen, Yumeng;Hu, Weiwei;Yang, Qian;Wei, Yanna;Feng, Zhixin

作者机构：

关键词： Vaccine Mhp-168 strain;Dendritic cells;Immune protection

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2017 年 13 卷

页码：

收录情况： SCI

摘要： Background: Mycoplasma hyopneumoniae (Mhp) causes porcine enzootic pneumonia, a disease that cause major economic losses in the pig industry. Dendritic cells (DCs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium, DCs uptake and present antigens to T cells, to initiate protective immune responses in different infections. In this study, we investigated the role of porcine DCs in vaccine Mhp-168 exposure. Results: The antigen presenting ability of DCs were improved by vaccine Mhp-168 exposure. DCs could activate T-cell proliferation by up-regulating the antigen presenting molecule MHCII expression and co-stimulatory molecule CD80/86. However, the up-regulation of IL-10 and accompany with down-regulation of IFN-gamma gene level may account for the limitation of attenuated Mhp-168 strain use as vaccine alone. Conclusion: These findings are benefit for exploring the protection mechanisms and the possible limitations of this attenuated Mhp-168 vaccine.

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