Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo
文献类型: 外文期刊
第一作者: Liu, Chuanmin
作者: Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang
作者机构:
关键词: Nitric oxide;GSNO;PCV2;PK-15 cells;BALB/c mice
期刊名称:BMC VETERINARY RESEARCH ( 影响因子:2.741; 五年影响因子:2.955 )
ISSN: 1746-6148
年卷期: 2017 年 13 卷
页码:
收录情况: SCI
摘要: Background: Nitric oxide (NO), an important signaling molecule with biological functions, has antimicrobial activity against a variety of pathogens including viruses. To our knowledge, little information is available about the regulatory effect of NO on porcine circovirus type 2 (PCV2) infection. This study was conducted to investigate the antiviral activity of NO generated from S-nitrosoglutathione (GSNO), during PCV2 infection of PK-15 cells and BALB/c mice. Results: GSNO released considerable NO in the culture medium of PK-15 cells, and NO was scavenged by its scavenger hemoglobin (Hb) in a dose-dependent manner. NO strongly inhibited PCV2 replication in PK-15 cells, and the antiviral effect was reversed by Hb. An in vivo assay indicated that GSNO treatment reduced the progression of PCV2 infection in mice, evident as reductions in the percentages of PCV2-positive sera and tissue samples and in the viral DNA copies in serum samples. GSNO also improved the growth performance and immune organs (spleens and thymuses) of the PCV2-infected mice to some degree. Conclusions: Our data demonstrate that the NO-generating compound GSNO suppresses PCV2 infection in PK-15 cells and BALB/c mice, indicating that NO and its donor, GSNO, have potential value as antiviral drugs against PCV2 infection.
分类号:
- 相关文献
作者其他论文 更多>>
-
Identification of the Effects of 5-Azacytidine on Porcine Circovirus Type 2 Replication in Porcine Kidney Cells
作者:Shan, Yiyi;Wu, Shenglong;Bao, Wenbin;Wu, Zhengchang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Wu, Zhengchang
关键词:5-Azacytidine; porcine circovirus type 2; porcine kidney cells
-
Identification of Cell Types and Transcriptome Landscapes of Porcine Epidemic Diarrhea Virus-Infected Porcine Small Intestine Using Single-Cell RNA Sequencing
作者:Fan, Baochao;Zhou, Jinzhu;Zhao, Yongxiang;Zhu, Xuejiao;Zhu, Mingjun;Peng, Qi;Li, Jizong;Chang, Xinjian;Shi, Danyi;Yin, Jie;Guo, Rongli;Li, Yunchuan;He, Kongwang;Li, Bin;Fan, Baochao;Zhou, Jinzhu;Zhao, Yongxiang;Zhu, Xuejiao;Zhu, Mingjun;Peng, Qi;Li, Jizong;Chang, Xinjian;Shi, Danyi;Yin, Jie;Guo, Rongli;Li, Yunchuan;He, Kongwang;Li, Bin;Fan, Huiying;Fan, Huiying;Li, Bin;Fan, Huiying;Li, Bin
关键词:
-
Transcriptomic and Proteomic Approaches Reveal the Biological Functions of Two Novel Porcine-Origin Noncoding DNA Molecules
作者:Wen, Libin;Xie, Jianping;Xiao, Qi;He, Kongwang;Wen, Libin;Xie, Jianping;Xiao, Qi;He, Kongwang;Wen, Libin;Xie, Jianping;Xiao, Qi;He, Kongwang;Wen, Libin;Xie, Jianping;Xiao, Qi;He, Kongwang;Wen, Libin;Xie, Jianping;Xiao, Qi;He, Kongwang
关键词:
-
A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets
作者:Li, Jizong;Zhao, Shuqing;Zhang, Baotai;Huang, Jin;Peng, Qi;Xiao, Li;Yuan, Xuesong;Guo, Rongli;Zhou, Jinzhu;Fan, Baochao;Zhu, Xuejiao;Liu, Chuanmin;Li, Bin;Li, Jizong;Li, Jizong;Xue, Tao;Liu, Chuanmin;Li, Jizong;Fan, Baochao;Zhu, Xuejiao;Liu, Chuanmin;Li, Bin;Li, Jizong;Fan, Baochao;Zhu, Xuejiao;Li, Bin;Li, Jizong;Huang, Jin;Yuan, Xuesong;Fan, Baochao;Zhu, Xuejiao;Li, Bin;Zhao, Shuqing;Ren, Lili;Zhang, Baotai;Xiao, Li;Zhu, Xing
关键词:porcine deltacoronavirus; S protein; subunit vaccine; piglets; sows; protective immunity
-
Exogenous nitric oxide generated from SNAP blocks porcine circovirus type 2 replication and regulates NF-kappa B activity in PK-15 cells
作者:Liu, Chuanmin;Wang, Zhisheng;Fu, Jinping;Liu, Chuanmin;Zhang, Qiannan;Zhang, Bo;Xue, Tao;Liu, Chuanmin;Wang, Zhisheng;Fu, Jinping;Liu, Chuanmin;Wang, Zhisheng;Fu, Jinping;Liu, Chuanmin;Liu, Chuanmin;Fu, Jinping;Xue, Tao
关键词:Nitric oxide; SNAP; Porcine circovirus type 2; PK-15 cells; NF-kappa B
-
Analysis on the genome of a teschovirus type 1 isolates with swine diarrhea
作者:Zhang, Baotai;Guo, Rongli;Xiao, Li;Zhong, Chunyan;Yuan, Xuesong;Huang, Jin;Zhu, Xuejiao;Zhou, Jinzhu;Fan, Baochao;Liu, Chuanmin;Li, Jizong;Li, Bin;Xue, Tao;Liu, Chuanmin;Li, Jizong;Fan, Baochao;Liu, Chuanmin;Li, Jizong;Li, Bin;Yuan, Xuesong;Huang, Jin;Zhu, Xuejiao;Fan, Baochao;Li, Jizong;Li, Bin;Zhang, Baotai;Xiao, Li;Zhu, Xing;Fan, Baochao;Li, Jizong;Li, Bin;Zhong, Chunyan;Li, Jizong
关键词:PTVs; High-throughput sequencing; VP1; Diarrhea; Phylogenetic analysis
-
Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis
作者:Chen, Jun;Li, Jingui;Fu, Jinping;Zhao, Sha;Zhang, Xiaoxi;Chao, Yuyang;Pan, Qunxing;Sun, Huawei;Zhang, Jingfeng;Li, Bin;Liu, Chuanmin;Fu, Jinping;Zhao, Sha;Zhang, Xiaoxi;Chao, Yuyang;Pan, Qunxing;Sun, Huawei;Zhang, Jingfeng;Li, Bin;Liu, Chuanmin;Fu, Jinping;Zhao, Sha;Zhang, Xiaoxi;Chao, Yuyang;Pan, Qunxing;Sun, Huawei;Zhang, Jingfeng;Li, Bin;Liu, Chuanmin;Xue, Tao;Liu, Chuanmin;Liu, Chuanmin;Liu, Chuanmin
关键词:viral infection; free radical; mitochondrion; ferroptosis