Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo
文献类型: 外文期刊
第一作者: Liu, Chuanmin
作者: Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang;Liu, Chuanmin;Wen, Libin;Xiao, Qi;He, Kongwang
作者机构:
关键词: Nitric oxide;GSNO;PCV2;PK-15 cells;BALB/c mice
期刊名称:BMC VETERINARY RESEARCH ( 影响因子:2.741; 五年影响因子:2.955 )
ISSN: 1746-6148
年卷期: 2017 年 13 卷
页码:
收录情况: SCI
摘要: Background: Nitric oxide (NO), an important signaling molecule with biological functions, has antimicrobial activity against a variety of pathogens including viruses. To our knowledge, little information is available about the regulatory effect of NO on porcine circovirus type 2 (PCV2) infection. This study was conducted to investigate the antiviral activity of NO generated from S-nitrosoglutathione (GSNO), during PCV2 infection of PK-15 cells and BALB/c mice. Results: GSNO released considerable NO in the culture medium of PK-15 cells, and NO was scavenged by its scavenger hemoglobin (Hb) in a dose-dependent manner. NO strongly inhibited PCV2 replication in PK-15 cells, and the antiviral effect was reversed by Hb. An in vivo assay indicated that GSNO treatment reduced the progression of PCV2 infection in mice, evident as reductions in the percentages of PCV2-positive sera and tissue samples and in the viral DNA copies in serum samples. GSNO also improved the growth performance and immune organs (spleens and thymuses) of the PCV2-infected mice to some degree. Conclusions: Our data demonstrate that the NO-generating compound GSNO suppresses PCV2 infection in PK-15 cells and BALB/c mice, indicating that NO and its donor, GSNO, have potential value as antiviral drugs against PCV2 infection.
分类号:
- 相关文献
作者其他论文 更多>>
-
DNMT3B inhibits PCV2 replication via targeting TMEM37 to regulate Ca2+influx in PK15 cells
作者:Du, Xiaomei;Yang, Li;Shan, Yiyi;Hu, Yueqing;Bao, Wenbin;Wu, Shenglong;Wu, Zhengchang;Bao, Wenbin;Wu, Shenglong;Wu, Zhengchang;Xiao, Qi
关键词:Pig; DNMT3B; PCV2 replication
-
The Isoforms of Ral Guanine Nucleotide Dissociation Stimulator (RalGDS) in LLC-PK1 Cells
作者:Song, Jingze;Li, Na;Dong, Xinze;Xie, Jianping;Lai, Hongqiao;Zhu, Hengzhi;He, Kongwang;Wen, Libin;Xiao, Qi;Xie, Jianping;He, Kongwang;Wen, Libin;Xiao, Qi;Xie, Jianping;He, Kongwang;Wen, Libin;Xiao, Qi;Xie, Jianping;He, Kongwang;Wen, Libin;Xiao, Qi;Suolang, Sizhu
关键词:RalGDS; isoform; LLC-PK1 cells; frameshift mutation; molecular evolution
-
Identification of the Effects of 5-Azacytidine on Porcine Circovirus Type 2 Replication in Porcine Kidney Cells
作者:Shan, Yiyi;Wu, Shenglong;Bao, Wenbin;Wu, Zhengchang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Xiao, Qi;He, Kongwang;Wu, Zhengchang
关键词:5-Azacytidine; porcine circovirus type 2; porcine kidney cells
-
Establishment of a duplex TaqMan-based real time RT-PCR assay for simultaneous detection of BRSV and BVDV
作者:Hao, Fuxing;Zhu, Daoxian;Cai, Bingyan;Li, Yuxin;Fu, Jinping;Chen, Jun;Liu, Chuanmin
关键词:bovine respiratory disease complex (BRDC); bovine respiratory syncytial virus (BRSV); bovine viral diarrhea virus (BVDV); TaqMan; duplex real-time RT-PCR
-
Frequency and Genetic Analysis of Porcine Circovirus Type 2, Which Circulated between 2014 and 2021 in Jiangsu, China
作者:Xiao, Qi;Qu, Meng;Xie, Jianping;Mao, Aihua;Qian, Wenxian;Zhu, Jiaping;Guo, Jiahui;Lang, Dong;Wen, Libin;He, Kongwang;Xiao, Qi;Xie, Jianping;Wen, Libin;He, Kongwang;Xiao, Qi;Xie, Jianping;Wen, Libin;He, Kongwang;Xiao, Qi;Xie, Jianping;Wen, Libin;He, Kongwang;Zhu, Cigen;Shan, Yuping;Niu, Jiaqiang
关键词:porcine circovirus type 2; Jiangsu Province; genetic analysis; genotype
-
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression
作者:Fan, Baochao;Li, Yupeng;Wang, Yi;Yang, Shanshan;Peng, Qi;Qian, Jiali;Wang, Chuanhong;Zhang, Xue;Xu, Hong;Liu, Shiyu;He, Wenlong;Zhang, Gege;Zhu, Xuejiao;Li, Yunchuan;Zhao, Yongxiang;Hu, Mi;Wang, Wei;Zhou, Jinzhu;Guo, Rongli;He, Kongwang;Li, Bin;Fan, Baochao;Li, Yupeng;Wang, Yi;Yang, Shanshan;Peng, Qi;Qian, Jiali;Wang, Chuanhong;Zhang, Xue;Xu, Hong;Liu, Shiyu;He, Wenlong;Zhang, Gege;Zhu, Xuejiao;Li, Yunchuan;Zhao, Yongxiang;Hu, Mi;Wang, Wei;Zhou, Jinzhu;Guo, Rongli;He, Kongwang;Li, Bin;Fan, Baochao;Yang, Shanshan;Peng, Qi;Zhu, Xuejiao;Li, Yunchuan;Zhao, Yongxiang;Hu, Mi;Wang, Wei;Zhou, Jinzhu;Guo, Rongli;He, Kongwang;Li, Bin;Fan, Baochao;Qian, Jiali;Liu, Shiyu;Li, Bin;Fan, Baochao;Fan, Baochao;Li, Bin;Li, Bin
关键词:
-
Identification of Cell Types and Transcriptome Landscapes of Porcine Epidemic Diarrhea Virus-Infected Porcine Small Intestine Using Single-Cell RNA Sequencing
作者:Fan, Baochao;Zhou, Jinzhu;Zhao, Yongxiang;Zhu, Xuejiao;Zhu, Mingjun;Peng, Qi;Li, Jizong;Chang, Xinjian;Shi, Danyi;Yin, Jie;Guo, Rongli;Li, Yunchuan;He, Kongwang;Li, Bin;Fan, Baochao;Zhou, Jinzhu;Zhao, Yongxiang;Zhu, Xuejiao;Zhu, Mingjun;Peng, Qi;Li, Jizong;Chang, Xinjian;Shi, Danyi;Yin, Jie;Guo, Rongli;Li, Yunchuan;He, Kongwang;Li, Bin;Fan, Huiying;Fan, Huiying;Li, Bin;Fan, Huiying;Li, Bin
关键词: