Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells

文献类型： 外文期刊

第一作者： Wang, Lin

作者： Wang, Lin;Mei, Mei;Qin, Aijian;Ye, Jianqiang;Qian, Kun;Shao, Hongxia;Wang, Lin;Mei, Mei;Qin, Aijian;Ye, Jianqiang;Qian, Kun;Shao, Hongxia;Qin, Aijian;Ye, Jianqiang;Qian, Kun;Shao, Hongxia;Qin, Aijian;Mei, Mei

作者机构：

期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）

ISSN： 0928-4249

年卷期： 2016 年 47 卷

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收录情况： SCI

摘要： We previously identified chicken Annexin A2 (chANXA2) as a novel receptor for retrovirus avian leucosis virus subgroup J (ALV-J), using a DF1 cell line expressing the viral envelope (env) protein. To further probe whether other proteins participate in virus infection, we investigated several host proteins from co-immunoprecipitation with the DF1 cell line expressing viral env. Mass spectrometry analysis indicates that the chicken glucose-regulation protein 78 (chGRP78) of the DF1 membrane interacted with the ALV-J env protein. The results revealed that antibodies or siRNA to chGRP78 significantly inhibited ALV-J infection and replication, and over-expression of chGRP78 enabled the entry of ALV-J into non-susceptible cells. Taken together, these results are the first to report that chGRP78 functions to help ALV-J enter cells.

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