Mapping Novel Loci and Candidate Genes Associated with Cadmium Content in Maize Using Genome-Wide Association Analysis

文献类型： 外文期刊

第一作者： Lai, Ruiqiang

作者： Lai, Ruiqiang;Xue, Xiaoming;Chachar, Zaid;Zhu, Hang;Hu, Yuanqiang;Chen, Ming;Li, Jiajia;Fan, Lina;Qi, Yongwen;Chen, Weiwei;Li, Xuhui;Zhang, Xiangbo

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关键词： maize; cadmium; candidate gene

期刊名称：AGRICULTURE-BASEL （ 影响因子：3.6； 五年影响因子：3.8 ）

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年卷期： 2025 年 15 卷 4 期

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收录情况： SCI

摘要： Cadmium is a toxic, carcinogenic element that threatens food safety due to its tendency to be absorbed by plants along with essential nutrients. This study conducted a genome-wide association study (GWAS) using SNP genotyping data from 170 natural maize populations to analyze cadmium content in maize grains across three environments. The MLM_Q+Kinship and MLM_PCA+Kinship models identified 6424 (HN), 991 (JMO), and 1358 (JMT) SNPs linked to cadmium accumulation in the MLM_Q+Kinship model, with 121 SNPs common across all environments. Additionally, the MLM_PCA+Kinship model detected 824 (HN), 950 (JMO), and 910 (JMT) SNPs, with 14 shared loci. In total, 126 reliable SNP loci, representing 14 QTLs, were identified, highlighting 12 superior haplotypes and 2 favorable alleles. A negative correlation between these loci and cadmium content was observed. Within 100 kbp of the QTLs, 45 candidate genes were identified, associated with 11 GO terms and 5 KEGG pathways. Analysis revealed 12 maize lines with at least one stable locus, all of which showed reduced Cd levels. Key hybrids, such as CAU95xCAU65 and CAU95xCAU266, demonstrated the potential for low Cd accumulation. This study provides valuable insights for breeding maize with reduced Cd uptake using stable gene loci discovered through GWAS.

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