Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea
文献类型: 外文期刊
第一作者: Tsigkou, Anastasia
作者: Tsigkou, Anastasia;Lee, Meng H.;Reis, Fernando M.;Ciarmela, Pasquapina;Ciarmela, Pasquapina;Jiang, Bingjie;Tosti, Claudia;Petraglia, Felice;Shen, Fang-Rong;Chen, You-Guo;Shi, Zhendan
作者机构:
关键词: leiomyoma;matrix metalloproteinase;dysmenorrhea;activin-A;myostatin;MMP14;abnormal uterine bleeding
期刊名称:REPRODUCTIVE SCIENCES ( 影响因子:3.06; 五年影响因子:3.109 )
ISSN: 1933-7191
年卷期: 2015 年 22 卷 12 期
页码:
收录情况: SCI
摘要: Uterine leiomyoma is the most common benign neoplasm of female reproductive system, found in about 50% of women in reproductive age. The mechanisms of leiomyoma growth include cell proliferation, which is modulated by growth factors, and deposition of extracellular matrix (ECM). Activin A and myostatin are growth factors that play a role in proliferation of leiomyoma cells. Matrix metalloproteinases (MMPs) are known for their ability to remodel the ECM in different biological systems. The aim of this study was to evaluate the expression levels of activin A-subunit, myostatin, and MMP14 messenger RNAs (mRNAs) in uterine leiomyomas and the possible correlation of these factors with clinical features of the disease. Matrix metalloproteinase 14 was highly expressed in uterine leiomyoma and correlated with myostatin and activin A mRNA expression. Moreover, MMP14 and myostatin mRNA expression correlated significantly and directly with the intensity of dysmenorrhea. Overall, the present findings showed that MMP14 mRNA is highly expressed in uterine leiomyoma, where it correlates with the molecular expression of growth factors and is further increased in cases of intense dysmenorrhea.
分类号:
- 相关文献
作者其他论文 更多>>
-
Integrative analysis of miRNA-mRNA expression in the brain during high temperature-induced masculinization of female Nile tilapia ( Oreochromis niloticus )
作者:Jiang, Bingjie;Lu, Siqi;Dong, Yalun;Xu, Pao;Qiang, Jun;Tao, Yifan;Li, Yan;Xu, Pao;Qiang, Jun;Badran, M. F.;Qiang, Jun;Tao, Yifan
关键词:Oreochromis niloticus; Brain tissues; High temperature -induced; Sex reversal; miRNA-mRNA expression
-
Improving duckling hatchability and quality by optimization of egg turning angle during incubation
作者:Chen, Fang;Zhu, Biwen;Guo, Binbin;Dai, Zichun;Ying, Shijia;Shi, Zhendan;Chen, Fang;Zhu, Biwen;Guo, Binbin;Dai, Zichun;Ying, Shijia;Shi, Zhendan;Zhu, Biwen;Huang, Yunmao;Shi, Zhendan
关键词:duck; egg turning angle; incubation; hatchability; growth performance
-
Effects of ambient temperature on growth performance, slaughter traits, meat quality and serum antioxidant function in Pekin duck
作者:Xu, Congcong;Sun, Dongyue;Liu, Yi;Pan, Ziyi;Dai, Zichun;Chen, Fang;Guo, Rihong;Chen, Rong;Shi, Zhendan;Ying, Shijia;Xu, Congcong;Sun, Dongyue;Liu, Yi;Shi, Zhendan;Ying, Shijia
关键词:Pekin duck; temperature; growth performance; slaughtering traits; meat quality; antioxidant function
-
Comparative transcriptomics and metabolomics reveal specific biochemical responses in cultured largemouth bass ( Micropterus salmoides ) juveniles with sexual dimorphism
作者:Li, Yan;Wang, Qingchun;Qiang, Jun;Xu, Pao;Li, Yan;Hua, Jixiang;Tao, Yifan;Lu, Siqi;Dong, Yalun;Jiang, Bingjie;Qiang, Jun;Xu, Pao
关键词:Largemouth bass; Sexual dependence; Lipid droplets; Differentially expressed genes; Differential metabolites
-
Ultrastructural, Antioxidant, and Metabolic Responses of Male Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) to Acute Hypoxia Stress
作者:Tao, Yifan;Hua, Jixiang;Lu, Siqi;Li, Yan;Jiang, Bingjie;Dong, Yalun;Qiang, Jun;Xu, Pao;Tao, Yifan;Wang, Qingchun;Qiang, Jun;Xu, Pao
关键词:hypoxia; GIFT; oxidative stress; metabolic adaptation; histology
-
The Impact of Different Relative Humidity Levels on the Production Performance, Slaughter Performance, and Meat Quality of White Pekin Ducks Aged 4 to 42 Days
作者:Sun, Dongyue;Ying, Shijia;Sun, Dongyue;Xu, Congcong;Liu, Yi;Dai, Zichun;Pan, Ziyi;Chen, Rong;Guo, Rihong;Chen, Fang;Shi, Zhendan;Ying, Shijia;Xu, Congcong;Liu, Yi
关键词:Pekin ducks; production performance; meat quality; humidity
-
Bacterial lipopolysaccharide with different administration routes affects intestinal mucosal morphological, immunological, and microbial barrier functions in goslings
作者:Xi, Yumeng;Li, Yue;Ying, Shijia;Yan, Junshu;Shi, Zhendan
关键词:gosling; lipopolysaccharide challenge; intestinal mucosal barrier function