Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

文献类型： 外文期刊

第一作者： Zheng, Liqiang

作者： Zheng, Liqiang;Zheng, Liqiang;Xu, Jiahui;Zheng, Jia;Xu, Qianyi;Zheng, Liqiang;Xu, Jiahui;Zheng, Jia;Xu, Qianyi;Xie, Yanxia;Sun, Zhaoqing;Zhang, Rui;Ma, Yanan;Ma, Yanan;Wen, Deliang;Li, Zhao;Guo, Xiaofan;Sun, Guozhe;Sun, Yingxian;Xing, Fuguo

作者机构：

关键词： spermidine; cardiovascular disease; nested case-control study; stroke; epidemiology

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies. Using a nested case-control study, we estimated the association between serum spermidine level and future stroke. New stroke cases had higher baseline levels of spermidine than controls [182.8 (141.8-231.5) vs. 152.0 (124.3-193.0), P < 0.001]. After multivariable adjustment, individuals with spermidine >= 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58-16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies. In addition, comparisons of the areas under receiver operator characteristics curves confirmed that a model including spermidine had better discrimination than without (0.755 vs. 0.715, P = 0.04). Here we report a close relationship exists between serum spermidine levels and risk of stroke.

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