Solomonseal Polysaccharide and Sulfated Codonopsis pilosula Polysaccharide Synergistically Resist Newcastle Disease Virus

文献类型： 外文期刊

第一作者： Liu, Cui

作者： Liu, Cui;Li, Entao;Wang, Deyun;Li, Peng;Li, Xiuping;Chen, Xingying;Qiu, Shulei;Gao, Zhenzhen;Hu, Yuanliang;Chen, Jin;Fan, Qiang;Zhang, Cunshuai;Li, Hongquan

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2015 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Five combinations of three ratios (PS9-sPS(1), PS7-sPS(3) and PS6-sPS(4)) were prepared with polysaccharide (PS) and sulfated polysaccharide (sPS). The antiviral activities of these compounds were subsequently compared in vitro using the MTT assay, observation of the virus structure and immunofluorescence. The results demonstrated that SP9-sCP(1), CP7-sCA(3), EP7-sAP(3), CA(9)-sEP(1) and EP7-sCA(3) presented higher activities, and SP9-sCP(1) displayed the highest virus inhibition rate and clearly killed the virus and inhibited viral antigen expression. In an in vivo test, 28-day-old chickens were challenged with Newcastle disease virus (NDV) and were administered the five drug combinations. On day 14 after the challenge, the morbidity, mortality and cure rate in each group were calculated. The results indicated that SP9-sCP(1) presented the lowest morbidity and mortality and the highest cure rate. These results indicate that Solomonseal polysaccharide and sulfated Codonopsis pilosula polysaccharide synergistically resist NDV. Moreover, SP9-sCP(1) had the highest efficacy and may be used as a new antiviral drug.

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