Reproductive toxicity in acrylamide-treated female mice

文献类型： 外文期刊

第一作者： Wei, Quanwei

作者： Wei, Quanwei;Li, Xingmei;Zhang, Lei;Shi, Fangxiong;Li, Jian

作者机构：

关键词： Acrylamide;Reproductive toxicity;Ovary;Nitric oxide synthase

期刊名称：REPRODUCTIVE TOXICOLOGY （ 影响因子：3.143； 五年影响因子：3.697 ）

ISSN： 0890-6238

年卷期： 2014 年 46 卷

页码：

收录情况： SCI

摘要： We investigated the reproductive toxicity of acrylamide in female mice. The results from immunohistochemistry provided evidence that nitric oxide synthase (NOS) signaling was involved in the process of follicular development and atresia. Oral administration of acrylamide to female mice led to significantly reduced body weights, organ weights and the number of corpora lutea (P < 0.05). Serum progesterone concentrations were significantly reduced (P < 0.05) concomitant with the increasing doses of acrylamide; however, 17 beta-estradiol (E2) concentrations were unchanged with treatment. Measurement of NOS activities indicated that total NOS (TNOS), iNOS and eNOS activities were significantly increased (P < 0.05) with increasing doses of acrylamide. The results from in vitro study indicated that acrylamide reduced the viability of mouse granulosa cells in a dose-dependent manner. In summary, acrylamide affected bodily growth and development, as well as reproductive organs, the number of corpora lutea and progesterone production in female mice, possibly acting through the NOS signaling pathway. (C) 2014 Elsevier Inc. All rights reserved.

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