Retinoid Regulation of the Zebrafish cyp26a1 Promoter

文献类型： 外文期刊

第一作者： Hu, Ping

作者： Hu, Ping;Bao, Jie;Gao, Xiang;Zhao, Qingshun;Tian, Miao;Gu, Xingxing;Xing, Guangdong;Linney, Elwood

作者机构：

关键词： zebrafish;cyp26a1;retinoic acid;transgenic zebrafish;retinoic acid response element;promoter

期刊名称：DEVELOPMENTAL DYNAMICS （ 影响因子：3.78； 五年影响因子：3.476 ）

ISSN： 1058-8388

年卷期： 2008 年 237 卷 12 期

页码：

收录情况： SCI

摘要： Cyp26A1 is a major enzyme that controls retinoic acid (RA) homeostasis by metabolizing RA into bio-inactive metabolites. Previous research revealed that the mouse Cyp26A1 promoter has two canonical RA response elements (RAREs) that underlie the regulation of the gene by RA. Analyzing the 2,533-base pairs (2.5 k) genomic sequence upstream of zebrafish cyp26a1 start codon, we report that the two RAREs are conserved in zebrafish cyp26a1 promoter. Mutagenesis demonstrated that the two RAREs work synergistically in RA inducibility of cyp26a1. Fusing the 2.5 k (kilobase pairs) fragment to the enhanced yellow fluorescent protein (eYFP) reporter gene, we have generated two transgenic lines of zebrafish [Tg(cyp26a1:eYFP)]. The transgenic zebrafish display expression patterns similar to that of cyp26a1 gene in vivo. Consistent with the in vitro results, the reporter activity is RA inducible in embryos. Taken together, our results demonstrate that the 2.5 k fragment underlies the regulation of the zebrafish cyp26a1 gene by RA. Developmental Dynamics 237:3798-3808, 2008. (c) 2008 Wiley-Liss, Inc.

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