The involvement of MsmK in pathogenesis of the Streptococcus suis serotype 2

文献类型： 外文期刊

第一作者： Tan, Mei-Fang

作者： Tan, Mei-Fang;Liu, Wan-Quan;Zhang, Chun-Yan;Zheng, Lin-Lin;Qiu, De-Xin;Li, Lu;Zhou, Rui;Tan, Mei-Fang;Gao, Ting;Li, Lu;Zhou, Rui

作者机构：

关键词： bloodstream;MsmK;pathogenesis;Streptococcus suis

期刊名称：MICROBIOLOGYOPEN （ 影响因子：3.139； 五年影响因子：3.503 ）

ISSN： 2045-8827

年卷期： 2017 年 6 卷 2 期

页码：

收录情况： SCI

摘要： Streptococcus suis serotype 2 (SS2) is an important swine and human pathogen that causes global economic and public health problems. Virulent S.suis strains successfully maintain high bacterial concentrations in host blood and rapidly adapt to challenging environments within hosts. Successful survival in hosts is a major factor influencing the pathogenesis of SS2. We have previously identified that SS2 colonization in mouse brain is possibly affected by the ATPase, MsmK of carbohydrate ATP-binding cassette (ABC) transporters because of carbohydrate utilization. In this study, the chain length of the msmK deletion mutant was longer than that of the wild type, and the former was significantly more susceptible than the latter when theses strains were exposed to mouse blood both in vivo and in vitro. The hemolytic activity of the mutant strain was decreased. Although the adhesion of the mutant to HEp-2 cell lines was enhanced, the deletion of msmK impaired the abilities of SS2 to resist phagocytosis and survive severe stress conditions. MsmK contributed to the survival and adaptation of SS2 in host bloodstream. Therefore, MsmK was identified as a multifunctional component that not only contributed to carbohydrate utilization but also participated in SS2 pathogenesis.

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